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Fecal sulfatide as a non-invasive biomarker for predicting coronary heart disease

Rui Hu1, Yihan Li2, Kefan Xue2

  • 1Clinical Laboratory, Beijing Hospital, National Center of Gerontology, Institute of Geriatric Medicine, chinese academy of medical scie, Beijing, China.

European Journal of Medical Research
|December 31, 2025
PubMed

Insights

Fecal sulfatide levels are significantly higher in patients with coronary heart disease (CHD). This novel, non-invasive biomarker shows strong potential for early CHD prediction and risk stratification.

Area of Science:

  • Biochemistry
  • Cardiovascular Medicine
  • Biomarker Discovery

Background:

  • Coronary heart disease (CHD) poses a significant global health burden.
  • Early detection and risk stratification are crucial for effective CHD management.
  • Non-invasive biomarkers are highly sought after for improved diagnostic strategies.

Purpose of the Study:

  • To investigate fecal sulfatide levels as a potential non-invasive biomarker for predicting coronary heart disease.
  • To compare fecal sulfatide levels across different CHD patient groups and healthy controls.
  • To assess the independent risk factor status and predictive value of fecal sulfatide for CHD.

Main Methods:

  • A retrospective study involving 593 CHD patients (acute myocardial infarction, unstable angina pectoris, stable angina pectoris) and 200 healthy controls.
  • Comparison of fecal sulfatide levels among the groups.
  • Binary logistic regression and multivariate logistic regression analyses to determine the correlation and independent risk factor status.
  • Receiver operating characteristic (ROC) curve analysis to evaluate predictive value.

Main Results:

  • Significant differences in demographic and clinical characteristics were observed between CHD patients and controls.
  • Fecal sulfatide levels were significantly elevated in all CHD groups compared to controls.
  • Fecal sulfatide levels were highest in the acute myocardial infarction group.
  • Fecal sulfatide was identified as an independent risk factor for CHD with strong predictive value (AUC = 0.893).

Conclusions:

  • Fecal sulfatide emerges as a promising novel, non-invasive biomarker for the early prediction and risk stratification of coronary heart disease.
  • The findings suggest potential clinical utility in identifying individuals at risk for CHD.
  • Further large-scale, multi-center prospective studies are warranted to validate these findings and confirm generalizability.
Abstract

Keywords:
Acute myocardial infarctionCoronary heart diseaseFecal sulfatideStable angina pectorisUnstable angina pectoris

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