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Related Concept Videos

Prevalence and Incidence01:08

Prevalence and Incidence

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In statistical epidemiology and health sciences, two essential metrics—prevalence and incidence—are fundamental for understanding disease dynamics within a population. These measures enable public health officials, epidemiologists, and researchers to assess the burden of diseases, allocate resources effectively, and design impactful public health policies and interventions.
Prevalence indicates the proportion of individuals in a population who have a specific disease or health...
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Rheumatic Heart Disease II: Clinical Manifestations and Diagnostic Studies01:22

Rheumatic Heart Disease II: Clinical Manifestations and Diagnostic Studies

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The key clinical manifestations of Rheumatic heart disease (RHD) include several distinct cardiac symptoms.Carditis, a hallmark of acute rheumatic fever, involves inflammation of the heart's endocardium, myocardium, and pericardium. Chronic RHD often results from recurrent episodes of carditis. Its symptoms include the following:Murmurs are caused by valvular damage, especially to the mitral and aortic valves. Mitral stenosis or regurgitation is common, with characteristic heart murmurs...
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Venous Thrombosis II: Clinical Manifestations and Diagnostic Studies01:20

Venous Thrombosis II: Clinical Manifestations and Diagnostic Studies

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The key difference between Superficial Vein Thrombosis (SVT) and Deep Vein Thrombosis (DVT) lies in their location and severity.Clinical ManifestationsSVT typically presents with localized pain, tenderness, and redness along the course of a superficial vein, often accompanied by a palpable, cord-like structure under the skin. This condition is usually less dangerous than DVT but can be uncomfortable and may lead to complications such as cellulitis or, rarely, a clot extension into the deep...
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Peripheral Arterial Disease II: Clinical Manifestations and Diagnostic Evaluation01:21

Peripheral Arterial Disease II: Clinical Manifestations and Diagnostic Evaluation

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Clinical manifestationsPeripheral Arterial Disease (PAD) manifests through a range of symptoms, from the characteristic intermittent claudication to atypical presentations and severe complications in advanced stages. Intermittent claudication, a hallmark symptom of PAD, presents as exercise-induced muscle pain that typically resolves within minutes of rest. This pain is reproducible and stems from inadequate blood flow, leading to the accumulation of lactic acid produced during anaerobic...
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Genome-wide Association Studies-GWAS01:11

Genome-wide Association Studies-GWAS

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Genome-wide association studies or GWAS are used to identify whether common SNPs are associated with certain diseases. Suppose specific SNPs are more frequently observed in individuals with a particular disease than those without the disease. In that case, those SNPs are said to be associated with the disease. Chi-square analysis is performed to check the probability of the allele likely to be associated with the disease.
GWAS does not require the identification of the target gene involved in...
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Rheumatic Heart Disease I: Introduction01:23

Rheumatic Heart Disease I: Introduction

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Rheumatic heart disease or RHD is a chronic condition that results from rheumatic fever, causing permanent damage to the heart valves.Etiology and Risk FactorsIt primarily arises from rheumatic fever, an inflammatory disease that can develop after untreated or inadequately treated group A streptococcal (GAS) pharyngitis. Streptococcus spreads through direct contact with oral or respiratory secretions. While the bacteria are the causative agents, factors like malnutrition, overcrowding, poor...
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Updated: Jan 7, 2026

Ultrasound Assessment of Endothelial-Dependent Flow-Mediated Vasodilation of the Brachial Artery in Clinical Research
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How common is vasculitis: what do population-based data tell us?

Anu Pandit1, Brian D Jaros, Anisha B Dua

  • 1Northwestern University Feinberg School of Medicine, Chicago, Illinois, USA.

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Summary
This summary is machine-generated.

Recent studies reveal global variations in systemic vasculitidies, influenced by genetics and environment. Advanced diagnostics and new criteria improve understanding of these vascular inflammatory diseases.

Keywords:
antineutrophil cytoplasmic antibody vasculitisepidemiologygiant cell arteritisvasculitis

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Area of Science:

  • Rheumatology
  • Immunology
  • Epidemiology

Background:

  • Systemic vasculitidies encompass diverse diseases marked by vascular inflammation.
  • Global prevalence and clinical features of these conditions vary significantly.

Purpose of the Study:

  • To review recent epidemiologic data and key findings on systemic vasculitidies.
  • To highlight advancements in understanding these disorders over the past 18 months.

Main Methods:

  • Review of recent scientific literature published within the last 18 months.
  • Analysis of updated epidemiologic studies and classification criteria.
  • Inclusion of data from underrepresented populations.

Main Results:

  • Advances in imaging, diagnostics, and therapeutics have reshaped the landscape of systemic vasculitidies.
  • New classification criteria enhance disease characterization and epidemiologic research.
  • Ethno-geographic variability, genetic, and environmental factors are crucial in pathogenesis, with emerging trends linked to genetic diversity.

Conclusions:

  • Systemic vasculitidies exhibit significant geographic, ethnic, and seasonal variability.
  • Advanced imaging and updated classification systems improve global disease burden assessment.
  • Epidemiologic studies from diverse populations offer critical insights into these inflammatory vascular diseases.