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The Synthesis, Characterization and Reactivity of a Series of Ruthenium N-triphosPh Complexes
Published on: April 10, 2015
Variations in the Coordination Sphere of Ruthenacyclic Carbamoyl Complexes: Mapping Their Suitability for Direct
Zhen Xuan Wong1, Chung Hean Lau1, Yongxin Li1
1School of Chemistry, Chemical Engineering and Biotechnology, Nanyang Technological University, 21 Nanyang Link, Singapore 637371.
Abstract:
The reactivity of a series of ruthenacyclic carbamoyl derivatives 4x, which are structural mimics of the [Fe]-hydrogenase metal cofactor, have been assessed in relation to their suitability for direct conjugation onto peptides. Substitution of a bromido ligand is specific for thiolates and selenolates, offering direct conjugation and precise control of the conjugation site. The ligand trans to the carbamoyl moiety is labile and, in certain solvents, may be uncoordinated. Steric effects from substitution at the 6-position of the aminopyridyl ring, or of the thiolato ligand in the thiolated derivatives, influence isomerization and dimerization, as well as efficacy and selectivity in catalytic organosilane hydrolysis.
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