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Updated: Jan 7, 2026
08:36
Functional Neuroimaging Using Ultrasonic Blood-brain Barrier Disruption and Manganese-enhanced MRI
Published on: July 12, 2012
15.4K
Gut to brain: essential micronutrient and trace element manganese transport, function and toxicity
Jiaqi Zou1, Riya Yerramilli1, Tolunay Beker Aydemir1
1Division of Nutritional Sciences, Cornell University, Ithaca, NY, United States.
Frontiers in Physiology
|January 1, 2026
Summary
This review details manganese (Mn) metabolism, covering its absorption, transport, and regulation. It emphasizes Mn
Area of Science:
- Physiology
- Neuroscience
- Toxicology
Background:
- Manganese (Mn) is essential but toxic in excess.
- Dysregulation of Mn homeostasis is linked to neurological disorders.
Purpose of the Study:
- To comprehensively review Mn metabolism and regulation.
- To explore Mn transport mechanisms and their role in health and disease.
Main Methods:
- Literature review of Mn absorption, excretion, distribution, and transport.
- Analysis of genetic and environmental factors influencing Mn homeostasis.
- Focus on Mn neurotoxicity and its mechanisms.
Main Results:
- Mn homeostasis involves complex interactions across the intestines, liver, and brain.
- Metal transporters play critical roles in systemic and brain Mn regulation.
- Mn dysregulation contributes to neurodegenerative conditions.
Conclusions:
- Understanding Mn transport is key to managing Mn homeostasis.
- This review bridges molecular mechanisms with whole-body physiology.
- Further research on Mn transporters can inform disease treatment.
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