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Detection of Invasive Pulmonary Aspergillosis in Haematological Malignancy Patients by using Lateral-flow Technology
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Therapeutic Drug Monitoring-Guided Antifungal Therapy Under Tyrosine Kinase Inhibitor Treatment in an Advanced

Ruiting Wen1, Wentao Ni2, Xiaotong Gu1,3

  • 1Department of Pharmacy, Peking University People's Hospital, Beijing, People's Republic of China.

Infection and Drug Resistance
|January 1, 2026
PubMed

Insights

Antifungal therapy for invasive pulmonary aspergillosis (IPA) in cancer patients requires personalized dosing. Therapeutic drug monitoring guided a switch from voriconazole to isavuconazole, improving outcomes and managing drug interactions.

Area of Science:

  • Medical Mycology
  • Pharmacokinetics
  • Oncology

Background:

  • Invasive pulmonary aspergillosis (IPA) poses a significant challenge in immunocompromised cancer patients.
  • Antifungal drug efficacy is often limited by interpatient pharmacokinetic variability and drug-drug interactions (DDIs).
Keywords:
apatinibinvasive pulmonary aspergillosisisavuconazolepharmacokineticsvoriconazole

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