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Adult-onset Still's disease presenting with aseptic meningitis: a case report

Xiao-Fen Li1, Amy Ker2,3, Hong-Li Liao1

  • 1Department of Rheumatology, Liuzhou People's Hospital, Guangxi Medical University, Liuzhou, Guangxi Zhuang Autonomous Region, China.

Frontiers in Immunology
|January 1, 2026
PubMed

Insights

Adult-onset Still's disease (AOSD) can cause rare, severe neurological issues like aseptic meningitis. This case highlights unusual complications and effective treatment strategies for this autoinflammatory disorder.

Area of Science:

  • Rheumatology
  • Neurology
  • Internal Medicine

Background:

  • Adult-onset Still's disease (AOSD) is a rare systemic autoinflammatory disorder.
  • Neurological involvement is an uncommon manifestation of AOSD.
  • The pathogenesis of AOSD and its neurological complications remain incompletely understood.
Keywords:
Yamaguchi criteriaadult-onset Still’s diseaseautoinflammatorycase-reporttocilizumab

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