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Engineered Biomimetic Nanomicelles Target Inflammation in Sepsis-Associated Acute Lung Injury by Scavenging ROS and

Quan Li1, Haijun Sun1, Xinjing Zhang2

  • 1Intensive Care Unit, Jiangsu Province (Suqian) Hospital, Suqian, Jiangsu, 223899, People's Republic of China.

International Journal of Nanomedicine
|January 1, 2026
PubMed
Summary
This summary is machine-generated.

A novel biomimetic nanodrug, MM@PT@CA, effectively treats sepsis-associated acute lung injury (SALI) by targeting inflammation and oxidative stress. This innovative treatment combats infection and shows promising therapeutic potential for SALI.

Keywords:
ROS scavengingacute lung injurybiomimetic nanomicellescarnosic acidmacrophage reprogramming

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Area of Science:

  • Biomedical Engineering
  • Nanotechnology
  • Pharmacology

Background:

  • Sepsis-associated acute lung injury (SALI) presents high mortality due to oxidative stress and inflammation.
  • Current treatments for SALI are limited.
  • A novel biomimetic nanodrug, MM@PT@CA, was developed using carnosic acid (CA) encapsulated in a copolymer (PT) and coated with M2 macrophage membranes (MM).

Purpose of the Study:

  • To develop and evaluate a novel biomimetic nanodrug for treating sepsis-associated acute lung injury (SALI).
  • To assess the ROS-responsive drug release, antioxidant, antibacterial, anti-inflammatory, and immunomodulatory properties of the nanodrug.
  • To evaluate the therapeutic efficacy of the nanodrug in a mouse model of SALI.

Main Methods:

  • Synthesis of PT copolymer and encapsulation of carnosic acid (CA) to form PT@CA micelles.
  • Coating PT@CA micelles with M2 macrophage membranes (MM) via co-extrusion to create MM@PT@CA.
  • In vitro and in vivo assessments of ROS scavenging, antioxidant, antibacterial, anti-inflammatory effects, M2 macrophage polarization, and therapeutic efficacy in a mouse SALI model.

Main Results:

  • MM@PT@CA demonstrated significant antioxidant activity, scavenging DPPH and ABTS radicals, and inhibited bacterial growth.
  • In vitro studies showed efficient cellular uptake, accumulation at inflammatory sites, excellent biocompatibility, restoration of cell viability under oxidative stress, and down-regulation of pro-inflammatory factors.
  • In vivo, MM@PT@CA treatment reduced apoptosis and effectively halted SALI progression by modulating macrophage polarization and inhibiting the cytokine storm.

Conclusions:

  • The developed bionic nanomicelle, MM@PT@CA, exhibits multifunctional efficacy in targeting inflammation, combating infection, and reducing oxidative stress.
  • MM@PT@CA effectively alleviates sepsis-associated acute lung injury (SALI) in a preclinical model.
  • This nanodrug holds significant therapeutic potential for the treatment of SALI.