Related Experiment Video

Updated: Jan 7, 2026

Assessment of Vascular Tone Responsiveness using Isolated Mesenteric Arteries with a Focus on Modulation by Perivascular Adipose Tissues
08:41

Assessment of Vascular Tone Responsiveness using Isolated Mesenteric Arteries with a Focus on Modulation by Perivascular Adipose Tissues

Published on: June 3, 2019

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FUNDC2 contributes to hypertensive vascular remodeling by regulating mitochondrial dynamics and ferroptosis in

Yuanyuan Jin1, Tingting Song1, Tingting Jiang1

  • 1Department of Cardiology, The First Affiliated Hospital of Harbin Medical University, Harbin, People's Republic of China.

Clinical and Experimental Hypertension (New York, N.Y. : 1993)
|January 1, 2026
PubMed
Abstract

Insights

Increased FUNDC2 in perivascular adipose tissue (PVAT) may drive hypertensive vascular remodeling by affecting mitochondrial dynamics and adipokine secretion. This research highlights FUNDC2 as a potential therapeutic target for hypertension.

Area of Science:

  • Cardiovascular Biology
  • Metabolic Research
  • Molecular Mechanisms of Disease

Background:

  • Perivascular adipose tissue (PVAT) plays a critical role in the development of vascular remodeling associated with hypertension.
  • Understanding the molecular mechanisms by which PVAT influences hypertensive vascular remodeling is crucial for developing effective treatments.

Purpose of the Study:

  • To investigate the specific molecular mechanisms of PVAT involvement in the onset and progression of hypertensive vascular remodeling.
  • To identify key proteins and pathways dysregulated in PVAT during hypertension.

Main Methods:

  • Proteomic analysis of thoracic aorta PVAT from spontaneously hypertensive rats (SHRs) and Wistar-Kyoto (WKY) rats.
  • Validation of differential protein expression using western blotting, immunohistochemistry, and transmission electron microscopy (TEM).
  • In vitro studies involving FUNDC2 knockdown in 3T3-L1 adipocytes and subsequent analysis of mitochondrial dynamics, ferroptosis, adipokine secretion, and vascular smooth muscle cell (VSMC) behavior.

Main Results:

  • Proteomics identified significantly upregulated FUNDC2 in the PVAT of SHRs compared to WKY rats.
  • Mitochondrial dynamics and ferroptosis-related proteins were significantly altered in SHR PVAT.
  • FUNDC2 knockdown in adipocytes reversed changes in mitochondrial dynamics, ferroptosis markers, and adipokine secretion, impacting VSMC phenotype and migration.

Conclusions:

  • Elevated FUNDC2 expression in PVAT may induce PVAT dysfunction and aberrant adipokine secretion.
  • These alterations, linked to mitochondrial dynamics and ferroptosis in PVAT adipocytes, contribute to hypertensive vascular remodeling.
  • FUNDC2 emerges as a potential molecular target for mitigating hypertensive vascular remodeling.
Keywords:
PVATferroptosishypertensionmitochondrial dynamicsvascular remodeling

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