[Inflamaging in elderly patients with sarcopenic obesity.]

The aim of the study was to investigate the relationship between C-reactive protein (C-RP), platelet-to-lymphocyte ratio (PLR), and the presence of sarcopenic obesity (SO) among elderly patients. Out of 380 elderly participants, 46 had SO, accounting for 12,1% of those examined. Of these, 69,6% were female and 30,4% were male. The comparison group included 52 elderly individuals without SO. Patients with SO were more likely to experience chronic non-communicable diseases, reduced physical activity, falls, cognitive impairments such as age-related memory loss, smoke more frequently, and drink alcohol less frequently. A significant increase in PLR and CRP values was associated with the SO status. A strong correlation between PLR and CRP indices was found (p=0,735, p<0,001). CRP had a negative association with muscle mass, walking speed, hand compression strength, and overall performance. The PLR index also had a negative correlation with these variables. A positive relationship was found between pbf and both CRP and PLR. ROC analysis allowed us to identify the PLR index as a predictor of SO with an AUC of 0,862 and a threshold value of 217. The sensitivity of the model was 86,4% and the specificity was 88,5%. The diagnostic effectiveness was 87,5%. Therefore, the PLR index can serve as an accessible marker for identifying elderly patients at high risk of SO when combined with CRP assessment.