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Cost Analysis of Risk-Stratified Retinopathy of Prematurity Screening

Hannah H Hwang1, Angelica Piccini2, Muhammad Abidi3

  • 1Department of Ophthalmology, Massachusetts Eye and Ear Infirmary, Boston, Massachusetts; Department of Ophthalmology, Boston Children's Hospital, Boston, Massachusetts.

Ophthalmology. Retina
|January 1, 2026
PubMed

Insights

Risk-stratified retinopathy of prematurity (ROP) screening can safely reduce hospital ROP exams. Implementing the TWO-ROP and FIRST-ROP algorithms can significantly lower neonatal healthcare costs in the US.

Area of Science:

  • Neonatal ophthalmology
  • Healthcare economics

Background:

  • Retinopathy of prematurity (ROP) is a leading cause of blindness in premature infants.
  • Current ROP screening protocols often involve frequent, resource-intensive inpatient examinations.

Purpose of the Study:

  • To evaluate the potential of risk-stratified ROP screening algorithms to optimize examination schedules.
  • To assess the impact of implementing the TWO-ROP and FIRST-ROP algorithms on neonatal healthcare costs.

Main Methods:

  • Analysis of risk-stratified screening protocols.
  • Economic modeling of algorithm implementation.

Main Results:

  • Risk-stratified screening demonstrates potential to maintain safety while decreasing the number of inpatient ROP examinations.
  • The TWO-ROP and FIRST-ROP algorithms show promise for significant reductions in US neonatal healthcare expenditures.

Conclusions:

  • Risk-stratified ROP screening offers a viable strategy to improve efficiency and reduce costs in neonatal care.
  • Adoption of the TWO-ROP and FIRST-ROP algorithms could lead to substantial financial savings within the US healthcare system.
Abstract

No abstract available in PubMed .

Keywords:
Cost analysisRetinopathy of prematurityRisk-stratified screening

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