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Association of life's simple 7 with cognitive function in a multi-ethnic cohort
Xiangyuan Huang1, Muhammad Haiman Bin Samad1, Gerald Choon Huat Koh1
1Saw Swee Hock School of Public Health, National University of Singapore and National University Health System, Singapore.
The Journal of Prevention of Alzheimer'S Disease
|January 1, 2026
Summary
A healthier lifestyle, measured by Life's Simple 7 (LS7), is linked to better cognitive function in Asians. However, LS7 did not predict changes in cognitive function over time.
Area of Science:
- Gerontology
- Public Health
- Neuroscience
Background:
- Cognitive health is influenced by multiple lifestyle factors, but few studies have examined these comprehensively, especially in Asian populations.
- The Singapore Multi-Ethnic Cohort study provides longitudinal data on lifestyle and cognitive function.
Purpose of the Study:
- To investigate the association between Life's Simple 7 (LS7) and cognitive function.
- To examine the relationship between LS7 and cognitive change over time in a multi-ethnic Asian population.
Main Methods:
- Longitudinal study of 2601 participants aged 45-86 years.
- LS7 score calculated at baseline; cognitive function assessed using Mini-Mental State Examination (MMSE) at two follow-ups.
- Linear quantile mixed models used to analyze associations and interactions with demographic factors.
Main Results:
- Higher LS7 scores were significantly associated with better MMSE scores across different percentiles.
- This association was stronger in older adults (≥60 years), those with higher education, and individuals of Chinese ethnicity.
- No significant association was found between LS7 and the change in MMSE scores over time.
Conclusions:
- A composite measure of a healthy lifestyle (LS7) is linked to better cognitive function in Asian adults.
- The benefits of LS7 on cognition are more pronounced in specific subgroups, including older adults, those with higher education, and the Chinese ethnicity.
- LS7 can be a valuable tool for modifying cognitive impairment risk in Asian populations.
Keywords:
Cognitive functionDietary patternLife’s simple 7Linear quantile mixed modelMini mental status examinationPhysical activityMore Related Videos
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