Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Epigenetic Regulation01:37

Epigenetic Regulation

3.7K
Epigenetic changes alter the physical structure of the DNA without changing the genetic sequence and often regulate whether genes are turned on or off. This regulation ensures that each cell produces only proteins necessary for its function. For example, proteins that promote bone growth are not produced in muscle cells. Epigenetic mechanisms play an essential role in healthy development. Conversely, precisely regulated epigenetic mechanisms are disrupted in diseases like cancer.
X-chromosome...
3.7K
Epigenetic Regulation01:46

Epigenetic Regulation

33.4K
Epigenetic mechanisms play an essential role in healthy development. Conversely, precisely regulated epigenetic mechanisms are disrupted in diseases like cancer.
33.4K
Cancer02:18

Cancer

53.4K
Cancers arise due to mutations in genes involved in the regulation of cell division, which leads to unrestricted cell proliferation. Modern science and medicine have made great strides in the understanding and treatment of cancer, including eradicating cancer in some patients. However, there is still no cure for cancer. This is largely due to the fact that cancer is a large group of many diseases.
53.4K
Genomic Imprinting and Inheritance02:30

Genomic Imprinting and Inheritance

36.7K
Diploid organisms inherit genetic material through chromosomes from both parents. Copies of the same gene are known as alleles. In most cases, both alleles are simultaneously expressed and allow various cellular processes to function optimally. If one of the alleles is missing or mutated, the expression of the other allele can compensate; however, this is not true for all genes.
The expression of some genes depends on which parent passed the gene to the offspring, through a phenomenon known as...
36.7K
Mitogens and the Cell Cycle02:38

Mitogens and the Cell Cycle

7.7K
Mitogens and their receptors play a crucial role in controlling the progression of the cell cycle. However, the loss of mitogenic control over cell division leads to tumor formation. Therefore, mitogens and mitogen receptors play an important role in cancer research. For instance, the epidermal growth factor (EGF) - a type of mitogen and its transmembrane receptor (EGFR), decides the fate of the cell's proliferation. When EGF binds to EGFR, a member of the ErbB family of tyrosine kinase...
7.7K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Efficacy of multipoint versus conventional biventricular pacing in CRT: systematic review and meta-analysis of randomized trials.

The Egyptian heart journal : (EHJ) : official bulletin of the Egyptian Society of Cardiology·2026
Same author

The use of cladribine tablets in patients with MS beyond the age of 50: experiences from a large tertiary German centre.

Neurological research and practice·2026
Same author

Circadian rhythms as orchestrators of breast cancer metastasis: From molecular mechanisms to chronotherapeutic interventions.

Cancer letters·2026
Same author

The potential of bee products in clinical trials focused on the side effects of radiotherapy and chemotherapy used for cancer treatment.

Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer·2026
Same author

Mechanisms of Resistance and Synergy: The Role of Tumor Microenvironment in HER2-Low Breast Cancer Therapy.

Pharmaceuticals (Basel, Switzerland)·2026
Same author

Integrating multi-omics and artificial intelligence for personalized breast cancer management: A guide to clinicians.

Cancer letters·2026

Related Experiment Video

Updated: Jan 7, 2026

An Integrated Platform for Genome-wide Mapping of Chromatin States Using High-throughput ChIP-sequencing in Tumor Tissues
10:41

An Integrated Platform for Genome-wide Mapping of Chromatin States Using High-throughput ChIP-sequencing in Tumor Tissues

Published on: April 5, 2018

10.8K

Mapping Non-Coding Epimutations in Breast Cancer: Advancing Epigenetics Towards Precision Medicine.

Mohamed E Abdel Aziz1, Heba Momtaz2, Basel Mohamed2

  • 1Department of Medical Biotechnology, College of Biotechnology, Misr University for Science and Technology, Giza, Egypt.

Sub-Cellular Biochemistry
|January 1, 2026
PubMed
Summary

The noncoding genome, including noncoding RNAs (ncRNAs), plays a critical role in breast cancer development and treatment resistance. Epigenetic modifications in these regions offer promising diagnostic and therapeutic strategies for personalized cancer care.

Keywords:
Breast cancerDNA methylationEpigeneticsNoncoding RNAsTherapeutic resistance

More Related Videos

Methyl-binding DNA capture Sequencing for Patient Tissues
08:40

Methyl-binding DNA capture Sequencing for Patient Tissues

Published on: October 31, 2016

9.0K
Methylated DNA Immunoprecipitation
21:24

Methylated DNA Immunoprecipitation

Published on: January 2, 2009

24.1K

Related Experiment Videos

Last Updated: Jan 7, 2026

An Integrated Platform for Genome-wide Mapping of Chromatin States Using High-throughput ChIP-sequencing in Tumor Tissues
10:41

An Integrated Platform for Genome-wide Mapping of Chromatin States Using High-throughput ChIP-sequencing in Tumor Tissues

Published on: April 5, 2018

10.8K
Methyl-binding DNA capture Sequencing for Patient Tissues
08:40

Methyl-binding DNA capture Sequencing for Patient Tissues

Published on: October 31, 2016

9.0K
Methylated DNA Immunoprecipitation
21:24

Methylated DNA Immunoprecipitation

Published on: January 2, 2009

24.1K

Area of Science:

  • Oncology
  • Genomics
  • Epigenetics

Background:

  • Breast cancer is a major global health concern, with research expanding beyond protein-coding genes.
  • The noncoding genome, encompassing various noncoding RNAs (ncRNAs), is increasingly recognized for its role in tumorigenesis and therapeutic resistance.
  • Epigenetic mechanisms like DNA methylation and histone modifications regulate ncRNAs, influencing breast cancer progression.

Purpose of the Study:

  • To comprehensively examine the role of the noncoding epigenome in breast cancer.
  • To highlight current methodologies, molecular mechanisms, and translational potential of ncRNA-based epigenetic alterations.
  • To identify future directions for personalized breast cancer care through noncoding epigenetics.

Main Methods:

  • Review of high-throughput techniques such as whole-genome bisulfite sequencing (WGBS), ATAC-seq, and ChIP-seq.
  • Analysis of epigenetic modifications (DNA methylation, histone modifications, m6A RNA methylation) affecting ncRNAs.
  • Exploration of ncRNA-based epigenetic alterations in specific breast cancer subtypes like TNBC and HER2-positive tumors.

Main Results:

  • Aberrant epigenetic modifications in noncoding regions can alter oncogene and tumor suppressor activity, contributing to breast cancer heterogeneity.
  • Noncoding epimutations discovered via high-throughput sequencing hold clinical significance.
  • ncRNA-based epigenetic alterations show potential as diagnostic biomarkers, prognostic indicators, and therapeutic targets.

Conclusions:

  • The noncoding epigenome is crucial in breast cancer pathogenesis and presents opportunities for personalized medicine.
  • Leveraging noncoding epigenetics requires further research to overcome challenges in functional element interpretation and clinical translation.
  • Future directions focus on integrating noncoding epigenetics for tailored breast cancer treatment strategies.