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Targeted Cancer Therapies02:57

Targeted Cancer Therapies

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The targeted cancer therapies, also known as “molecular targeted therapies,” take advantage of the molecular and genetic differences between the cancer cells and the normal cells. It needs a thorough understanding of the cancer cells to develop drugs that can target specific molecular aspects that drive the growth, progression, and spread of cancer cells without affecting the growth and survival of other normal cells in the body.
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Cancers arise due to mutations in genes involved in the regulation of cell division, which leads to unrestricted cell proliferation. Modern science and medicine have made great strides in the understanding and treatment of cancer, including eradicating cancer in some patients. However, there is still no cure for cancer. This is largely due to the fact that cancer is a large group of many diseases.
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An Overview of Targeting Some Cancer Hallmarks with Plant Polyphenols: A Step Toward Precision.

Nadia M Hamdy1, Amr Amin2,3,4, Gamal Eldein Fathy Abd-Ellatef5

  • 1Biochemistry and Molecular Biology Department, Faculty of Pharmacy, Ain Shams University, Cairo, Egypt.

Sub-Cellular Biochemistry
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PubMed
Summary

Polyphenols (PPs), plant compounds, show potent anticancer activity by inhibiting tumor growth and enhancing chemotherapy. Advanced nano-formulations improve their effectiveness and safety for cancer treatment.

Keywords:
AntioxidantsCancerChemotherapyDrug deliveryEpigeneticsFlavonoidsMDRNanotechnologyPP

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Area of Science:

  • Phytochemistry
  • Pharmacology
  • Oncology

Background:

  • Polyphenols (PPs) are abundant plant secondary metabolites with diverse medicinal properties.
  • PPs modulate critical pathways in oncogenesis, epigenetics, and tumorigenesis.
  • They exhibit anticancer effects by inhibiting proliferation, metastasis, and chemoresistance.

Purpose of the Study:

  • To highlight the potential of polyphenols (PPs) in cancer therapy.
  • To review recent advances in polyphenol formulation for cancer targeting.

Main Methods:

  • Review of clinical and preclinical studies (in vitro and in vivo).
  • Analysis of polyphenol coadministration with conventional chemotherapy.
  • Evaluation of advanced polyphenol nano-formulations.

Main Results:

  • PPs demonstrate significant anticancer activity.
  • Combined PPs and chemotherapy improve treatment efficiency and safety.
  • Nano-formulations enhance polyphenol bioavailability and efficacy.

Conclusions:

  • Polyphenols show considerable promise as anticancer agents.
  • Advanced formulations like nano-formulations are key to maximizing therapeutic benefits.
  • PPs represent a valuable strategy for novel cancer treatment approaches.