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Related Concept Videos

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Updated: Jan 7, 2026

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Spiro-Conjugated π-σ-π Architectures Enable Single-Molecule Insulators via Destructive Quantum Interference.

Zhe-Hong Yu1, Chengjia Jing2,3, Yang-Kun Qu1

  • 1State Key Laboratory of Bioinspired Interfacial Materials Science, Institute of Functional Nano & Soft Materials (FUNSOM), Soochow University, Suzhou, Jiangsu, 215123, P.R. China.

Angewandte Chemie (International Ed. in English)
|January 2, 2026
PubMed
Summary
This summary is machine-generated.

Researchers explored destructive quantum interference (DQI) in molecular electronics using pi-sigma-pi systems. This study reveals a new molecular design strategy for advanced single-molecule devices by controlling conductance beyond HOMO-LUMO interactions.

Keywords:
Quantum interferenceSingle‐molecule electronicsSpiro‐conjugationπ‐σ‐π structure

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Area of Science:

  • Molecular electronics
  • Quantum interference phenomena
  • Organic electronics

Background:

  • Controlling molecular conductance is crucial for single-molecule electronics.
  • Highest occupied molecular orbital and lowest unoccupied molecular orbital (HOMO-LUMO) interference is a known factor.
  • Destructive quantum interference (DQI) offers a route to lower conductance.

Purpose of the Study:

  • To investigate DQI in pi-sigma-pi molecular frameworks.
  • To explore the role of bilateral interference in molecular conductance.
  • To establish a molecular design strategy for single-molecule devices.

Main Methods:

  • Utilized linear diphenylmethane and orthogonal 9,9'-spirobifluorene frameworks.
  • Designed four model molecules (DM22-MT, DM44-MT, SF33-MT, SF44-MT) with -SMe anchoring groups.
  • Employed scanning tunneling microscope-break junction (STM-BJ) measurements and theoretical simulations.

Main Results:

  • All examined molecules exhibited intrinsically low conductance, consistent with DQI.
  • Site-dependent effects in spiro systems disrupted conjugation and altered coupling.
  • Observed counterintuitive conductance trends in spiro systems.

Conclusions:

  • Provided the first experimental evidence for bilateral DQI in pi-sigma-pi systems.
  • Established a molecular design strategy for insulating and functionalized single-molecule devices.
  • Demonstrated control over molecular conductance beyond HOMO-LUMO interference.