Osteoporosis-mediated exacerbation of the amyloid-β pathology: Involvement of serum calcium
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Updated: Jan 7, 2026

Visualization of Amyloid β Deposits in the Human Brain with Matrix-assisted Laser Desorption/Ionization Imaging Mass Spectrometry
Published on: March 7, 2019
Zhe-Sheng Zhang1, Rong-Rong Lin1, Xu Liu1
1Department of Neurology, The Second Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, China.
Abstract:
Alzheimer's disease (AD) and osteoporosis (OP) are two common age-related degenerative diseases with similar epidemiological characteristics, yet their complex relationship and specific mechanistic intersections remain unclear. In this study, 775 individuals were divided into OP and non-OP groups. Results showed that OP was associated with elevated serum calcium levels and severer amyloid-β (Aβ) pathology. Regression analysis indicated a positive correlation between serum calcium and Aβ PET levels. Mediation analysis further elucidated that serum calcium involved in the OP-mediated exacerbation of Aβ pathology. These findings suggested that serum calcium may be a bridge in the complex association between OP and AD.
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