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Updated: Jan 7, 2026

Inherent Dynamics Visualizer, an Interactive Application for Evaluating and Visualizing Outputs from a Gene Regulatory Network Inference Pipeline
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DISTRIBUTED DELAY STABILIZES BISTABLE GENETIC NETWORKS.

Sean Campbell1, Courtney C White1, Amanda M Alexander1,2

  • 1Department of Mathematics, University of Houston, Houston, Texas, USA.

Arxiv
|January 2, 2026
PubMed
Summary
This summary is machine-generated.

Increasing noise in protein production delays stabilizes biological switches in genetic circuits. This finding enhances understanding of biological systems and aids synthetic biology design.

Keywords:
bistabilitydelay stochastic simulation algorithmdistributed delaygenetic regulatory networkstabilization of metastable statesswitching between delay distributions

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Area of Science:

  • Systems Biology
  • Synthetic Biology
  • Biophysics

Background:

  • Genetic regulatory networks (GRNs) exhibit inherent delays due to complex protein production processes.
  • These delays are often distributed (random) due to inherent noise in molecular events like transcription and translation.

Purpose of the Study:

  • To investigate the impact of distributed delays on the dynamics of bistable genetic circuits.
  • To understand how noise in protein production affects the stability of biological switches.

Main Methods:

  • Simulation of stochastic hybrid models with a switching-rate parameter.
  • Generalization and analysis of the three-states model for bistability.

Main Results:

  • Increased noise in the delay distribution significantly stabilizes metastable states in bistable genetic circuits.
  • Mean residence times in metastable states are dramatically increased with higher noise levels.

Conclusions:

  • Distributed delays and their associated noise play a crucial role in stabilizing biological switches.
  • Understanding these stabilization mechanisms can inform the design of robust synthetic genetic circuits.