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De novo arthropathy following glucocorticoid treatment for severe alcohol-associated hepatitis: Five case reports
Queralt Herms1, Sonia Torres1, Patrick S Kamath2
1Liver Unit, Hospital Clínic de Barcelona, Barcelona 08036, Catalonia, Spain.
Background:
Glucocorticoids (GC) are the cornerstone in the treatment of severe alcohol-associated hepatitis (SAH) but may be associated with adverse events.
Case Summary:
We report a prospective series of patients with SAH who were treated with GC and developed de novo arthropathy within 2 weeks of GC cessation. Five patients were included in this series, three of whom were women. All patients underwent ultrasound evaluation and were referred to the Rheumatology Clinics. Final diagnoses were: Arthralgia associated with GC cessation (n = 3), polymyalgia rheumatica (n = 1) and psoriatic arthritis (n = 1). Joint soreness was the main symptom, whereas arthritis occurred rarely. Patients with arthralgia associated with GC cessation required longer regimes of GC and tapering strategies but remained free of symptoms and specific treatment in the long term.
Conclusion:
De novo arthropathy may occur following GC for SAH. Close monitoring and tapering regimes are advised.
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