Microplastics in metabolic dysfunction-associated steatotic liver disease: An emerging threat to liver health

Area of Science:

• Environmental Health
• Hepatology
• Toxicology

Background:

• Metabolic dysfunction-associated steatotic liver disease (MASLD) is a growing global health concern linked to environmental and lifestyle factors.
• Microplastics (MPs) are ubiquitous environmental pollutants detected in human organs, including the liver, raising concerns about their health impacts.
• The specific role of MPs in MASLD pathogenesis remains incompletely understood.

Purpose of the Study:

• To comprehensively review the impact of microplastic exposure on hepatic metabolism.
• To analyze the effects of MPs on mitochondrial homeostasis and the endocrine system in the context of liver disease.
• To explore the potential implications of MPs for the progression of MASLD.

Main Methods:

• Literature review of studies investigating microplastic exposure and liver health.
• Analysis of research on the effects of microplastics on metabolic pathways.
• Examination of data on microplastic interactions with mitochondrial and endocrine functions.

Main Results:

• Microplastic exposure can disrupt hepatic metabolic processes.
• MPs may negatively affect mitochondrial homeostasis, crucial for liver function.
• Evidence suggests potential impacts on the endocrine system, influencing liver health.

Conclusions:

• Microplastics represent a potential environmental risk factor contributing to MASLD development and progression.
• Understanding the interplay between MPs and hepatic metabolism is critical for addressing the growing MASLD epidemic.
• Further research is warranted to elucidate the direct and indirect effects of MPs on liver pathogenesis.