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Global research trends in signaling pathways of spasmolytic polypeptide-expressing metaplasia pathogenesis: a

Qiumiao Xu1,2, Zhijiang Dai1,2, Chengjin Peng1,2

  • 1Department of Spleen and Stomach, Shenzhen Hospital (Futian) of Guangzhou University of Chinese Medicine, Shenzhen, China.

Frontiers in Oncology
|January 2, 2026
PubMed
Abstract

Insights

This bibliometric analysis maps research on signaling pathways in spasmolytic polypeptide-expressing metaplasia (SPEM) pathogenesis. It identifies key insights and future directions for combating gastric precancerous lesions.

Area of Science:

  • Gastroenterology and Molecular Biology
  • Cancer Research
  • Bibliometric Analysis

Background:

  • Signaling pathways are crucial in spasmolytic polypeptide-expressing metaplasia (SPEM) pathogenesis, especially in gastric cancer precursor lesions.
  • Global research trends in SPEM pathogenesis signaling pathways are not well-defined.
  • This study addresses this gap through bibliometric analysis.

Purpose of the Study:

  • To conduct a comprehensive bibliometric analysis of signaling pathways in SPEM pathogenesis.
  • To map the research field, identify key insights, and guide future research.
  • To inform strategic planning and foster collaboration in SPEM research.

Main Methods:

  • Bibliometric analysis and knowledge mapping using CiteSpace and VOSviewer.
  • Inclusion of articles and reviews from the Web of Science Core Collection.
  • Data analysis of publications, institutions, authors, journals, and countries.

Main Results:

  • 89 papers from 21 countries/regions were analyzed, showing slow publication growth.
  • The United States and China lead in publications; *Gastroenterology* is a leading journal.
  • Research focuses on gene-pathway interplay and cytokines, guiding development of targeted pharmacological agents for gastric precancerous lesions.

Conclusions:

  • This systematic review provides guidance for future research and collaboration in SPEM pathogenesis.
  • There is a need for strengthened interdisciplinary and global partnerships.
  • The findings highlight a shift towards targeted therapies for gastric precancerous lesions.
Keywords:
CiteSpaceVOSviewerbibliometricsknowledge mappingsignaling pathwayspasmolytic polypeptide-expressing metaplasia

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