Search research articles

ABOUT JoVE

Overview Leadership Blog JoVE Help Center

AUTHORS

Publishing Process Editorial Board Scope & Policies Peer Review FAQ Submit

LIBRARIANS

Testimonials Subscriptions Access Resources Library Advisory Board FAQ

RESEARCH

JoVE Journal Methods Collections JoVE Encyclopedia of Experiments Archive

EDUCATION

JoVE Core JoVE Business JoVE Science Education JoVE Lab Manual Faculty Resource Center Faculty Site

Terms & Conditions of Use

Related Concept Videos

Parkinson's Disease: Treatment

Parkinson's Disease: Treatment

Neurodegenerative disorders, such as Parkinson's Disease (PD), involve the gradual and irreversible destruction of neurons in particular brain areas. These disorders exhibit standard features like proteinopathies, selective vulnerability of some neurons, and an interaction of intrinsic properties, genetics, and environmental influences in neural injury.
Parkinson's Disease is primarily a result of the loss of dopaminergic neurons in the substantia nigra pars compacta. The cornerstone of...

Parkinson's Disease: Overview

Parkinson's Disease: Overview

Neurodegenerative disorders are progressive diseases that cause irreversible damage and loss to neurons in specific brain areas. Examples of these disorders include Parkinson's disease, Alzheimer's disease, Multiple Sclerosis (MS), and Amyotrophic Lateral Sclerosis (ALS). These disorders share characteristics such as proteinopathies, selective neuronal vulnerability, and a complex interplay between genetic and environmental factors. The primary therapeutic goal for these conditions is...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by

Same author

Reduced pre-movement subthalamic beta desynchronization marks motor deficit in Parkinson's disease.

Brain communications·2026

Same author

N2G calibrator: a cross-subject adversarial learning framework for neural signal-driven gait tracking in Parkinson's disease.

Communications engineering·2026

Same author

N2G calibrator: a cross-subject domain adversarial training framework for gait tracking from neural signals in Parkinson's disease.

medRxiv : the preprint server for health sciences·2025

Same author

Beta burst-driven adaptive deep brain stimulation for gait impairment and freezing of gait in Parkinson's disease.

Brain communications·2025

Same author

Subthalamic Nucleus Deep Brain Stimulation Alleviates the Sequence Effect and Freezing of Gait in Parkinson's Disease.

medRxiv : the preprint server for health sciences·2025

Same author

The Skin-to-Mucosa Ratio Defines the Osteogenic Potential of Lip Fibroblasts.

Journal of dental research·2025

Search research articles

Related Experiment Video

Updated: Jan 7, 2026

Controlling Parkinson's Disease With Adaptive Deep Brain Stimulation

Controlling Parkinson's Disease With Adaptive Deep Brain Stimulation

Published on: July 16, 2014

Low-Frequency Adaptive Deep Brain Stimulation for Parkinson's Disease.

A S Negi¹, C Cui¹, K B Wilkins¹

¹Department of Neurology and Neurological Sciences, Stanford University, Stanford, CA, USA.

Medrxiv : the Preprint Server for Health Sciences

|January 2, 2026

Summary

Low-frequency deep brain stimulation (DBS) at 60 Hz improved freezing of gait in Parkinson's disease patients. Adaptive DBS (aDBS) and continuous DBS (cDBS) showed gait benefits, but not broad motor symptom relief.

Keywords:

beta burst closed-loop DBS freezing of gait gait impairment subthalamic nucleus

More Related Videos

Author Spotlight: Automated Deep Brain Stimulation for Parkinson's Disease - Exploring the Possibilities and Challenges of Home Monitoring

Author Spotlight: Automated Deep Brain Stimulation for Parkinson's Disease - Exploring the Possibilities and Challenges of Home Monitoring

Published on: July 14, 2023

Targeting Neuronal Fiber Tracts for Deep Brain Stimulation Therapy Using Interactive, Patient-Specific Models

Targeting Neuronal Fiber Tracts for Deep Brain Stimulation Therapy Using Interactive, Patient-Specific Models

Published on: August 12, 2018

Related Experiment Videos

Last Updated: Jan 7, 2026

Controlling Parkinson's Disease With Adaptive Deep Brain Stimulation

Controlling Parkinson's Disease With Adaptive Deep Brain Stimulation

Published on: July 16, 2014

Author Spotlight: Automated Deep Brain Stimulation for Parkinson's Disease - Exploring the Possibilities and Challenges of Home Monitoring

Author Spotlight: Automated Deep Brain Stimulation for Parkinson's Disease - Exploring the Possibilities and Challenges of Home Monitoring

Published on: July 14, 2023

Targeting Neuronal Fiber Tracts for Deep Brain Stimulation Therapy Using Interactive, Patient-Specific Models

Targeting Neuronal Fiber Tracts for Deep Brain Stimulation Therapy Using Interactive, Patient-Specific Models

Published on: August 12, 2018

Area of Science:

Neuroscience
Neurology
Biomedical Engineering

Background:

Freezing of gait (FOG) is a progressive and debilitating Parkinson's disease (PD) symptom.
Adaptive deep brain stimulation (aDBS) shows promise for managing fluctuating PD symptoms.
Low-frequency stimulation (LFS) may offer additional gait benefits in moderate-to-advanced PD.

Purpose of the Study:

To evaluate the efficacy of 60 Hz continuous deep brain stimulation (cDBS).
To assess the safety, tolerability, and feasibility of 60 Hz adaptive deep brain stimulation (aDBS).

Main Methods:

Eight individuals with PD received bilateral subthalamic nucleus leads and the Summit RC+S system.
60 Hz aDBS was calibrated to adjust stimulation based on beta bursts.
Participants underwent blinded, randomized testing during a FOG-eliciting task under OFF DBS, 60 Hz cDBS, and 60 Hz aDBS.

Main Results:

60 Hz cDBS was tolerated by 6/8 participants and reduced beta burst duration.
60 Hz aDBS was safe and tolerable.
Gait improved in participants with baseline FOG during both 60 Hz aDBS and cDBS.

Conclusions:

60 Hz aDBS and cDBS benefit PD patients with baseline FOG.
These LFS protocols may not provide broad motor symptom relief compared to high-frequency stimulation (HFS).
Personalized DBS programming by identifying LFS responders is crucial.