Re-Epithelialization Comparison Between Topical Administration of 1% Feracrylum and Silver Sulfadiazine in the...

The gold standard burn dressing silver sulfadiazine (SSD) is widely used, but many disadvantages have been reported. An alternative is 1% feracrylum (1FA), a hemostatic agent that provides antibacterial activity, and wound improvement has been clinically proven. This study aimed to investigate the effect of 1FA in re-epithelization in burn wound management. This experimental study used 27 healthy male Wistar rats. All received inhalation anesthesia, then were prepared for deep burn injury using a metal plate. The animals were treated with either 1FA, SSD, or moist saline gauze (control group). The wound was measured with a two-ruler method on days 0, 5, 10 and 14. On day 14, quantitative and qualitative assessments of re-epithelialization were made. The percentage of wound healing was significantly better in the 1FA group compared to the control and SSD groups (p <0.001 on day 5; p<0.001 on day 10, and p <0.001 on day 14). The histopathology evaluation revealed that the epithelial thickness was significantly greater in the 1FA group compared to the control and SSD groups (p<0.001). The granulation tissue thickness was greater in the SSD group compared to the control and 1FA groups (p<0.001). The neovascularization in the 1FA group was more mature compared to the control and SSD groups (p<0.001). In this animal study, 1FA administration showed improved wound healing and re-epithelialization of the skin after deep dermal burns. These findings may lead to a new therapeutic approach for burn wound healing.