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Updated: Jan 7, 2026

Analysis of Extracellular Vesicle-Mediated Vascular Calcification Using In Vitro and In Vivo Models
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Analysis of Extracellular Vesicle-Mediated Vascular Calcification Using In Vitro and In Vivo Models

Published on: January 27, 2023

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Mechanism and treatment of Sirtuin family in vascular calcification

Zhexue Ren1, Beibei Song2, Yinying Peng1

  • 1School of Clinical Medicine, Shandong Second Medical University, Weifang, China.

Frontiers in Cardiovascular Medicine
|January 2, 2026
PubMed

Insights

Vascular calcification (VC) is increasing with aging populations. The Silent Information Regulator (SIRT) family shows promise in treating VC by targeting cellular aging mechanisms.

Area of Science:

  • Biomedical Science
  • Molecular Biology
  • Gerontology

Background:

  • Vascular calcification (VC) prevalence rises with population aging, affecting individuals with hypertension, diabetes, and chronic kidney disease.
  • VC involves abnormal calcium phosphate deposition in vascular walls, representing a form of vascular aging with no current pharmacological treatments.
  • The Silent Information Regulator (SIRT) family (SIRT1-SIRT7) comprises deacetylases crucial for cellular processes including aging and metabolism, earning them the name 'longevity proteins'.

Purpose of the Study:

  • To explore the therapeutic potential of the SIRT family in mitigating vascular calcification.
  • To investigate the mechanisms by which SIRT proteins may suppress VC, including their role in cellular aging pathways.

Main Methods:

  • Review of existing literature on SIRT family functions and their involvement in vascular aging and calcification.
  • Analysis of studies demonstrating the effects of SIRT activation or modulation on cellular processes relevant to VC.

Main Results:

  • SIRT proteins can alleviate vascular aging by inhibiting inflammation, reducing endoplasmic reticulum stress, and lowering mitochondrial oxidative stress.
  • SIRT family members, particularly SIRT1, SIRT2, SIRT3, SIRT6, and SIRT7, have shown potential in promoting DNA damage repair, a key factor in suppressing VC.
  • These mechanisms collectively contribute to the suppression of vascular calcification.

Conclusions:

  • The SIRT family holds significant therapeutic promise for treating vascular calcification.
  • Targeting SIRT pathways may offer a novel pharmacological strategy to combat VC and associated vascular aging.

Keywords:
Sirtuin familyinflammationoxidative stressvascular calcificationvascular smooth muscle cells

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