Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Steady, Laminar Flow Between Parallel Plates01:17

Steady, Laminar Flow Between Parallel Plates

754
Understanding steady, laminar flow between parallel plates is essential for analyzing and designing flow in narrow rectangular channels, commonly found in various water conveyance and drainage systems. The Navier-Stokes equations govern fluid motion and are generally challenging to solve due to their nonlinearity. However, simplifications are possible in certain cases, like the steady laminar flow between parallel plates. For this scenario, we assume steady, incompressible, laminar flow.
754
Couette Flow01:22

Couette Flow

863
Couette flow represents the flow of fluid between two parallel plates, with one plate fixed and the other moving with a constant velocity. This configuration allows for a simplified analysis using the Navier-Stokes equations, which govern fluid motion under conditions of viscosity and incompressibility. For Couette flow, the assumptions include a steady, laminar, incompressible flow with a zero-pressure gradient in the flow direction. This flow type is beneficial for understanding shear-driven...
863
Laminar Flow01:27

Laminar Flow

2.1K
Laminar flow represents a smooth, orderly fluid motion where particles move along parallel paths, resulting in minimal mixing between layers. Streamlined particle paths characterize this flow regime and occur under conditions where viscous forces dominate over inertial forces. The distinction between laminar, transitional, and turbulent flow is primarily determined by the Reynolds number, a dimensionless quantity calculated as:
2.1K
Steady, Laminar Flow in Circular Tubes01:23

Steady, Laminar Flow in Circular Tubes

983
Hagen-Poiseuille flow describes a viscous fluid's steady, incompressible flow through a cylindrical tube with a constant radius R. This flow profile is often applied to understand fluid transport in narrow channels, such as capillaries. It serves as a foundational example of laminar flow. In this model, cylindrical coordinates (r,θ,z) are used to describe the radial (r), angular (θ), and axial (z) dimensions within the tube. For Hagen-Poiseuille flow, the velocity profile is purely axial,...
983
Laminar Flow: Problem Solving01:24

Laminar Flow: Problem Solving

478
Laminar flow occurs when a fluid moves smoothly in parallel layers with minimal mixing and turbulence. In fluid mechanics, ensuring laminar flow within a pipe is essential for precise control of flow characteristics, especially in engineering applications. The key factor in determining whether flow remains laminar is the Reynolds number, a dimensionless quantity that depends on the fluid's velocity, density, viscosity, and the pipe's diameter. A Reynolds number of 2100 or lower...
478

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Scaling of deterministic lateral displacement devices to a single column of bumping obstacles.

Lab on a chip·2020
Same author

An in vitro tumor swamp model of heterogeneous cellular and chemotherapeutic landscapes.

Lab on a chip·2020
Same author

Large-Area Resistive Strain Sensing Sheet for Structural Health Monitoring.

Sensors (Basel, Switzerland)·2020
Same author

Hybrid LAE-CMOS Force-Sensing System Employing TFT-Based Compressed Sensing for Scalability of Tactile Sensing Skins.

IEEE transactions on biomedical circuits and systems·2019
Same author

Generation of Heterogeneous Drug Gradients Across Cancer Populations on a Microfluidic Evolution Accelerator for Real-Time Observation.

Journal of visualized experiments : JoVE·2019
Same author

The role of heterogeneous environment and docetaxel gradient in the emergence of polyploid, mesenchymal and resistant prostate cancer cells.

Clinical & experimental metastasis·2019
Same journal

Microfluidic rare cell analysis beyond counting: workflow design from enrichment to multi-omics.

Lab on a chip·2026
Same journal

A sperm racetrack to separate sperm by swim speed.

Lab on a chip·2026
Same journal

Controlled encapsulation and droplet size prediction in two-step microfluidic double emulsions.

Lab on a chip·2026
Same journal

A particulate blood-mimicking fluid with physiological biconcave geometry for microscale hemorheology.

Lab on a chip·2026
Same journal

Multicellular sensor arrays fabricated by capillary stamping for pattern-based odor discrimination.

Lab on a chip·2026
Same journal

A real-time microfluidic surveillance system for multiplex detection of heavy metal contamination in wastewater.

Lab on a chip·2026
See all related articles

Related Experiment Video

Updated: Jan 7, 2026

Tuning a Parallel Segmented Flow Column and Enabling Multiplexed Detection
08:01

Tuning a Parallel Segmented Flow Column and Enabling Multiplexed Detection

Published on: December 15, 2015

7.9K

Tunable single-column deterministic lateral displacement device by adjustable crossflow.

Miftahul Jannat Rasna1, James C Sturm1

  • 1Department of Electrical and Computer Engineering, Princeton University, Princeton, New Jersey, 08544, USA. mrasna@princeton.edu.

Lab on a Chip
|January 2, 2026
PubMed
Summary
This summary is machine-generated.

This study introduces a tunable deterministic lateral displacement (DLD) device for size-based micro-particle separation. The novel single-column design offers adjustable critical size and high throughput, overcoming limitations of conventional DLD systems.

More Related Videos

Design and Characterization Methodology for Efficient Wide Range Tunable MEMS Filters
15:25

Design and Characterization Methodology for Efficient Wide Range Tunable MEMS Filters

Published on: February 4, 2018

6.5K
High-precision Electromagnetic Flowmeter with Empty Pipe Detection via Complex Programmable Logic Device-based Waveform Recognition
05:11

High-precision Electromagnetic Flowmeter with Empty Pipe Detection via Complex Programmable Logic Device-based Waveform Recognition

Published on: June 27, 2025

590

Related Experiment Videos

Last Updated: Jan 7, 2026

Tuning a Parallel Segmented Flow Column and Enabling Multiplexed Detection
08:01

Tuning a Parallel Segmented Flow Column and Enabling Multiplexed Detection

Published on: December 15, 2015

7.9K
Design and Characterization Methodology for Efficient Wide Range Tunable MEMS Filters
15:25

Design and Characterization Methodology for Efficient Wide Range Tunable MEMS Filters

Published on: February 4, 2018

6.5K
High-precision Electromagnetic Flowmeter with Empty Pipe Detection via Complex Programmable Logic Device-based Waveform Recognition
05:11

High-precision Electromagnetic Flowmeter with Empty Pipe Detection via Complex Programmable Logic Device-based Waveform Recognition

Published on: June 27, 2025

590

Area of Science:

  • Microfluidics
  • Biotechnology
  • Particle Separation Technology

Background:

  • Deterministic lateral displacement (DLD) devices enable high-resolution, size-based micro-particle separation using tilted micro-post arrays.
  • Conventional DLD devices lack tunability in critical particle size (Dc), which is fixed by geometry.
  • Traditional DLD devices require large footprints due to multiple rows/columns for particle separation, limiting throughput.

Purpose of the Study:

  • To develop a novel, tunable single-column deterministic lateral displacement (DLD) device.
  • To overcome the fixed critical size limitation of conventional DLD devices.
  • To enhance throughput and reduce device area for micro-particle separation.

Main Methods:

  • A single-column DLD device with 8 bumping obstacles was designed and fabricated.
  • Tunability of critical size (Dc) was achieved by adjusting perpendicular crossflow.
  • Device performance was evaluated for separation efficiency and throughput/area.

Main Results:

  • Demonstrated tunability of critical size (Dc) from below 5 μm to above 10 μm within a single device.
  • Achieved high separation efficiency of approximately 99.9%.
  • Obtained a high throughput/area of 45 μL min⁻¹ mm⁻².
  • Noted resolution degradation at high flow rates (Re > 10) due to 3D flow patterns.

Conclusions:

  • The novel tunable single-column DLD device offers a significant advancement over conventional designs.
  • This technology provides a compact and adaptable solution for precise micro-particle separation.
  • Further research may focus on optimizing performance at higher flow rates.