Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Anticoagulant Drugs: Low-Molecular-Weight Heparins01:30

Anticoagulant Drugs: Low-Molecular-Weight Heparins

1.6K
Hemostasis is a crucial process that prevents excessive blood loss from damaged blood vessels. It involves various mechanisms such as vasoconstriction, platelet adhesion and activation, and fibrin formation. The importance of each mechanism depends on the type of vessel injury. In contrast, thrombosis is the abnormal formation of a blood clot within the blood vessels, leading to potential complications if the clot obstructs blood flow. Thrombosis can be caused by increased coagulability of the...
1.6K
Disorders of Hemostasis01:24

Disorders of Hemostasis

1.9K
Hemostasis, the process that stops bleeding after a blood vessel injury, is crucial for maintaining the integrity of the circulatory system. However, disorders of hemostasis can disrupt this delicate balance, leading to either excessive clotting or bleeding. These disorders can be broadly classified into thromboembolic disorders and bleeding disorders.
Thromboembolic Disorders
Two factors primarily cause thromboembolic conditions.
1.9K
Probability Laws01:49

Probability Laws

43.8K
Overview
43.8K
Venous Thrombosis III: Interprofessional Care01:29

Venous Thrombosis III: Interprofessional Care

257
Venous thrombosis requires effective prevention and treatment strategies to improve patient outcomes and reduce potential complications.Prevention StrategiesHealthcare providers must prioritize preventing venous thromboembolism (VTE) for all adult patients upon admission. Interventions depend on bleeding and thrombosis risk, medical history, current medications, diagnoses, planned procedures, and patient preferences. Patients on bed rest should change positions every two hours and, if not...
257
Pedigree Analysis01:35

Pedigree Analysis

88.7K
Overview
88.7K
Venous Thrombosis I: Introduction01:30

Venous Thrombosis I: Introduction

267
Venous thrombosis, the most common disorder of the veins, involves the formation of a thrombus or blood clot associated with vein inflammation. It can be classified as either superficial vein thrombosis or deep vein thrombosis.Superficial Vein Thrombosis: This involves the formation of a thrombus in a superficial vein, usually the greater or lesser saphenous vein. Though less severe than deep vein thrombosis (DVT), SVT can lead to complications if untreated.Deep Vein Thrombosis (DVT): This...
267

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same authorSame journal

From curiosity to clinical relevance: Rethinking genetic mosaicism.

Journal of the American Association of Nurse Practitioners·2026
Same author

Recognizing repeat expansion disorders in clinical practice.

Journal of the American Association of Nurse Practitioners·2026
Same author

Understanding mosaicism: A primer for clinicians.

Journal of the American Association of Nurse Practitioners·2026
Same author

DNA sequencing in newborn screening.

Journal of the American Association of Nurse Practitioners·2025
Same journal

A low-cost approach to national surveys of the nurse practitioner workforce in a resource-constrained environment.

Journal of the American Association of Nurse Practitioners·2026
Same journal

Drug pricing policy and its impact on clinical practice.

Journal of the American Association of Nurse Practitioners·2026
Same journal

Preclinical objective structured clinical examination for Family Nurse Practitioner students: Impact on clinical confidence and perceptions of curricular integration.

Journal of the American Association of Nurse Practitioners·2026
Same journal

Under fire: Federal policy shifts and the impact on gender minority college students.

Journal of the American Association of Nurse Practitioners·2026
Same journal

Metastatic pleural mesothelioma presenting as ulcerated submucosal colonic nodules.

Journal of the American Association of Nurse Practitioners·2026
See all related articles

Related Experiment Video

Updated: Jan 7, 2026

Measurement of Factor V Activity in Human Plasma Using a Microplate Coagulation Assay
13:08

Measurement of Factor V Activity in Human Plasma Using a Microplate Coagulation Assay

Published on: September 9, 2012

19.3K

Inherited thrombophilias: Genetics and testing considerations.

Mindy B Tinkle1

  • 1University of New Mexico College of Nursing, Albuquerque, New Mexico.

Journal of the American Association of Nurse Practitioners
|January 2, 2026
PubMed
Summary
This summary is machine-generated.

Inherited thrombophilias increase venous thromboembolism (VTE) risk, but most individuals do not develop VTE. Selective genetic testing can improve VTE prevention and avoid unnecessary screening.

Keywords:
Factor V Leidenprothrombinpulmonary embolismrisk assessmentthrombophilia, hereditaryvenous thromboembolism

More Related Videos

A Method to Study the C924T Polymorphism of the Thromboxane A2 Receptor Gene
07:00

A Method to Study the C924T Polymorphism of the Thromboxane A2 Receptor Gene

Published on: April 1, 2019

10.3K
Genetic Analysis of Hereditary Transthyretin Ala97Ser Related Amyloidosis
06:33

Genetic Analysis of Hereditary Transthyretin Ala97Ser Related Amyloidosis

Published on: June 9, 2018

8.1K

Related Experiment Videos

Last Updated: Jan 7, 2026

Measurement of Factor V Activity in Human Plasma Using a Microplate Coagulation Assay
13:08

Measurement of Factor V Activity in Human Plasma Using a Microplate Coagulation Assay

Published on: September 9, 2012

19.3K
A Method to Study the C924T Polymorphism of the Thromboxane A2 Receptor Gene
07:00

A Method to Study the C924T Polymorphism of the Thromboxane A2 Receptor Gene

Published on: April 1, 2019

10.3K
Genetic Analysis of Hereditary Transthyretin Ala97Ser Related Amyloidosis
06:33

Genetic Analysis of Hereditary Transthyretin Ala97Ser Related Amyloidosis

Published on: June 9, 2018

8.1K

Area of Science:

  • Genetics
  • Hematology
  • Clinical Medicine

Background:

  • Inherited thrombophilias are genetic conditions predisposing individuals to venous thromboembolism (VTE), including deep vein thrombosis and pulmonary embolism.
  • Despite genetic predisposition, the majority of individuals with thrombophilia do not experience VTE events.
  • Prevalence and VTE risk vary among the five classic inherited thrombophilias (Factor V Leiden, prothrombin G20210A, protein C deficiency, protein S deficiency, antithrombin deficiency), influenced by zygosity and coinheritance.

Purpose of the Study:

  • To review current clinical guidelines and evidence regarding inherited thrombophilia testing.
  • To highlight the role of advanced practice nurses in VTE risk assessment and management.
  • To emphasize the benefits of selective thrombophilia testing in enhancing VTE prevention.

Main Methods:

  • Review of current clinical guidelines from major professional organizations (e.g., American Hematology Association, American College of Obstetricians and Gynecologists).
  • Analysis of the evidence base supporting thrombophilia testing recommendations, noting limitations due to low-certainty outcome data.
  • Discussion of practical clinical scenarios and the role of advanced practice providers in decision-making.

Main Results:

  • Current guidelines generally discourage universal thrombophilia screening, advocating for testing only when results impact management or family screening.
  • Evidence supporting these guidelines is often of low certainty, leading to conflicting recommendations and clinical uncertainty.
  • Advanced practice nurses are crucial in personalized risk assessment, guiding testing, interpreting results, and coordinating patient care.

Conclusions:

  • Selective, rather than universal, inherited thrombophilia testing can be a valuable tool for VTE prevention.
  • Judicious use of thrombophilia testing, guided by individualized risk assessment, can optimize patient care and resource allocation.
  • Further high-quality outcome data is needed to refine evidence-based guidelines for thrombophilia testing.