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Thyroid Nodule Molecular Classifiers-Reclaiming Deliberation in an Era of Automation

Juan P Brito1,2, David Toro-Tobon1,2, Victor M Montori1,2

  • 1Care and AI Laboratory, Knowledge and Evaluation Research Unit, Mayo Clinic, Rochester, Minnesota.

JAMA Oncology
|January 2, 2026
PubMed
Abstract

No abstract available in PubMed .

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Low blood levels of the thyroid hormones — triiodothyronine (T3) and thyroxine (T4) — signal the hypothalamus to release the thyrotropin-releasing hormone (TRH). TRH then reaches the pituitary gland and stimulates the release of thyroid-stimulating hormone(TSH) into the bloodstream.
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The thyroid gland is a small, butterfly-shaped gland located in the neck and covers the anterior surface of the trachea. The gland has two lateral lobes connected by a thin tissue mass called the isthmus. Internally, each lobe comprises many small spherical structures known as thyroid follicles, surrounded by a network of blood vessels.
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