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Updated: Jan 7, 2026

Enzymatic Cascade Reactions for the Synthesis of Chiral Amino Alcohols from L-lysine
Published on: February 16, 2018
A Multicatalytic Cascade for the Stereoselective Synthesis of 1,4-Chiral Nitro Alcohols
Christian Ascaso-Alegre1, Álvaro Linacero-Gracia1, Patricia Ferreira2
1Institute of Chemical Synthesis and Homogeneous Catalysis (ISQCH), Spanish National Research Council (CSIC)-University of Zaragoza, Pedro Cerbuna 12, 50009 Zaragoza, Spain.
Abstract:
Artificial cascades offer a powerful strategy to access high-value chemicals efficiently. Here, we report the integration of metal catalysis, organocatalysis, and biocatalysis in a one-pot stereodivergent process to synthesize chiral 1,4-nitro alcohols bearing two stereocenters. Optimization of each step enabled the efficient and selective formation of all four diastereomers with excellent stereoselectivity (up to 97:3 dr and er) and good yields. This work highlights the potential of multicatalytic cascades for the synthesis of stereochemically rich molecules.
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