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Related Concept Videos

Mechanical Ventilation II: Invasive Ventilation01:23

Mechanical Ventilation II: Invasive Ventilation

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Ventilators are essential medical equipment used to aid patients with respiratory difficulties. Their primary function is to assist or replace spontaneous breathing by providing mechanical ventilation. There are two general classes of mechanical ventilators: negative-pressure and positive-pressure ventilators.
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Mechanical Ventilation I: Indication and Settings01:29

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Mechanical ventilation is a life-saving technique for managing acute respiratory failure and other respiratory complications. The process involves using a machine known as a ventilator to supply oxygen to the lungs and assist in removing carbon dioxide. It serves as a bridge to long-term mechanical ventilation or a temporary measure until ventilatory support is discontinued. The ventilator can maintain this function for a prolonged period, providing critical support for patients until they can...
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Acute Kidney Injury V: Interprofessional Care01:20

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Acute Kidney Injury (AKI) requires a collaborative healthcare approach to restore renal function and prevent complications. Essential management strategies involve monitoring fluid and electrolyte balance, adjusting medications, initiating dialysis when necessary, and providing nutritional support.Fluid and Electrolyte ManagementFluid Monitoring: Regularly monitoring body weight, central venous pressure, and urine output helps detect fluid imbalances early. Patient intake and output are...
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Mechanical Ventilation III: Noninvasive Ventilation01:23

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Noninvasive positive-pressure ventilation (NIPPV), continuous positive airway pressure (CPAP), and bilevel positive airway pressure (BiPAP) are essential methods in respiratory care. These ventilation techniques offer unique benefits for patients with various respiratory conditions, providing adequate support without requiring intubation. Let's explore how each method is crucial in improving patient outcomes and enhancing respiratory therapy.
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Ventilatory Modes01:14

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Mechanical ventilators are life-saving devices that support or replace spontaneous breathing. They deliver breaths to patients through varying methods known as ventilator modes. Understanding these modes is critical for healthcare providers managing patients with respiratory failure.
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Normothermic Ex Vivo Kidney Perfusion for the Preservation of Kidney Grafts prior to Transplantation
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Kidney-ventilator interaction and kidney-protective ventilation.

Prit Kusirisin1,2, Sean M Bagshaw1

  • 1Department of Critical Care Medicine, Faculty of Medicine and Dentistry, University of Alberta, and Alberta Health Services, Edmonton, Alberta, Canada.

Current Opinion in Critical Care
|January 2, 2026
PubMed
Summary
This summary is machine-generated.

Invasive mechanical ventilation can harm kidneys, but lung-protective ventilation strategies may help. Understanding lung-kidney interactions is crucial for critically ill patients.

Keywords:
acute kidney injuryacute respiratory failurelung–kidney interactionmechanical ventilationrenal replacement therapy

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Area of Science:

  • Critical Care Medicine
  • Nephrology
  • Pulmonology

Background:

  • Invasive mechanical ventilation (IMV) is vital for acute respiratory failure (ARF) and acute respiratory distress syndrome (ARDS).
  • Positive pressure ventilation (PPV) and injurious IMV can lead to renal dysfunction.
  • The interplay between ARF/ARDS and acute kidney injury (AKI) significantly impacts patient outcomes.

Purpose of the Study:

  • To review current evidence on kidney-ventilator interactions.
  • To explore strategies for kidney-protective ventilation during IMV.

Main Methods:

  • Review of existing literature on lung-kidney interactions in critically ill patients.
  • Analysis of how ventilation strategies affect renal function.
  • Evaluation of extracorporeal organ support in managing IMV-associated AKI.

Main Results:

  • PPV and injurious IMV can cause hemodynamic and neurohormonal changes, impairing kidney function and promoting biotrauma.
  • AKI can negatively affect pulmonary function, creating a bidirectional injury.
  • Lung-protective ventilation (LPV) with low tidal volumes and conservative fluid management may mitigate AKI.
  • Extracorporeal organ support, including renal replacement therapy and ECMO, may aid LPV and improve outcomes in patients with IMV-associated AKI.

Conclusions:

  • IMV and the lungs/kidneys interact bidirectionally.
  • LPV and extracorporeal organ support show promise in mitigating dual organ injury.
  • Understanding lung-kidney interactions is essential for optimizing care in critically ill patients on IMV.