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Inertial Cavitation-based Release Estimation - ICbRE.

Benedikt George1, Ula Savšek2, Jan Helmerich1

  • 1University of Freiburg, Department of Microsystems Engineering, Georges-Koehler-Allee 106, Freiburg im Breisgau, 79110, Baden-Wurttemberg, Germany.

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|January 2, 2026
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Summary
This summary is machine-generated.

This study introduces an Inertial Cavitation-based Release Estimation (ICbRE) method to quantify drug release from carriers. The technique uses cavitation noise to accurately estimate drug payload release during focused ultrasound cancer therapy.

Keywords:
Biomedical ultrasoundDrug delivery (DD)Focused ultrasound (FUS)Inertial cavitation (IC)PLGA nanocapsules (NCs)Release estimation

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Area of Science:

  • Biomedical Engineering
  • Acoustic Physics
  • Nanotechnology

Background:

  • Cancer research utilizes drug carriers for localized tumor treatment.
  • Accurate quantification of drug release is crucial for effective cancer therapy.
  • Focused ultrasound is a promising modality for triggering drug release.

Purpose of the Study:

  • To develop and validate a novel method for quantifying drug release from nanocarriers.
  • To establish a correlation between inertial cavitation noise and drug release.
  • To propose an integrated system for real-time monitoring of drug delivery during focused ultrasound treatment.

Main Methods:

  • Poly(lactic-co-glycolic acid) (PLGA) nanocapsules loaded with fluorescent dye were used.
  • Focused ultrasound (550-950 kHz) was applied to a tissue-mimicking phantom containing nanocapsules.
  • Inertial cavitation (IC) noise was recorded using a passive cavitation detection (PCD) system.
  • Weight functions were derived from acoustic data to estimate payload release.

Main Results:

  • The Inertial Cavitation-based Release Estimation (ICbRE) method demonstrated high precision.
  • The most accurate estimation achieved an absolute error of 0.3% and a standard deviation of 1.9%.
  • A strong correlation was found between recorded cavitation noise and actual drug release.

Conclusions:

  • ICbRE offers a precise method for quantifying drug release from carriers using focused ultrasound.
  • The proposed method can be integrated into focused ultrasound systems for real-time therapeutic monitoring.
  • This technology has the potential to enhance the efficacy and safety of cancer treatments involving drug delivery.