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Chromatin Modification in iPS Cells

Chromatin Modification in iPS Cells

Chromatin modification alters gene expression; therefore, scientists can add histone-modifying enzymes, histone variants, and chromatin remodeling complexes to somatic cells to aid reprogramming into pluripotent stem (iPS) cells.
Compact chromatin makes reprogramming difficult. Enzymes, such as histone demethylases and acetyltransferases, are often added during reprogramming to loosen the chromatin, making the DNA more accessible to transcription factors. Molecules that inhibit histone...

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Updated: Jan 7, 2026

Flow Cytometry-based Drug Screening System for the Identification of Small Molecules That Promote Cellular Differentiation of Glioblastoma Stem Cells

Flow Cytometry-based Drug Screening System for the Identification of Small Molecules That Promote Cellular Differentiation of Glioblastoma Stem Cells

Published on: January 10, 2018

Key methylation modifications in glioma stem cells.

Lize Cai¹, Xun Sun², Rong Li¹

¹Department of Neurosurgery, Changhai Hospital, Second Military Medical University (Naval Medical University), Shanghai 200433, China.

Biochimica Et Biophysica Acta. Reviews on Cancer

|January 2, 2026

Summary

Glioma stem cells (GSCs) drive glioblastoma (GBM) aggressiveness and resistance. Methylation of DNA, RNA, and proteins critically regulates GSC plasticity and offers potential diagnostic markers.

Keywords:

Biomarkers Epigenetic regulation Glioma stem cell Methylation

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Last Updated: Jan 7, 2026

Flow Cytometry-based Drug Screening System for the Identification of Small Molecules That Promote Cellular Differentiation of Glioblastoma Stem Cells

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Published on: January 10, 2018

Quantitative Immunohistochemistry of the Cellular Microenvironment in Patient Glioblastoma Resections

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Published on: July 31, 2017

LINE-1 Methylation Analysis in Mesenchymal Stem Cells Treated with Osteosarcoma-Derived Extracellular Vesicles

LINE-1 Methylation Analysis in Mesenchymal Stem Cells Treated with Osteosarcoma-Derived Extracellular Vesicles

Published on: February 1, 2020

Area of Science:

Neuro-oncology
Cancer Stem Cell Biology
Epigenetics

Background:

Glioblastoma (GBM) is an aggressive brain tumor with poor prognosis.
Glioma stem cells (GSCs) drive GBM heterogeneity, therapeutic resistance, and recurrence.
GSCs possess self-renewal, differentiation, and tumor-initiating capabilities, contributing to invasiveness and immune modulation.

Purpose of the Study:

To review the critical role of methylation dynamics in GSCs.
To explore recent advancements in DNA, RNA, and protein methylation research within GSCs.
To propose a regulatory network for methylation in GSCs and identify potential clinical markers.

Main Methods:

Comprehensive literature review of GSC biology and methylation.
Analysis of epigenetic mechanisms, including DNA, RNA, and protein methylation.
Synthesis of current research to propose a regulatory network.

Main Results:

GSCs exhibit metabolic reprogramming supporting their aggressive phenotype and epigenetic remodeling.
Methylation of DNA, RNA, and proteins is crucial for regulating GSC plasticity, gene expression, and signaling pathways.
Understanding methylation dynamics in GSCs is key to addressing therapeutic resistance.

Conclusions:

Methylation plays a pivotal role in GSC characteristics and GBM progression.
Further research into methylation networks in GSCs can enhance therapeutic strategies.
Methylation-based biomarkers hold promise for improved GBM diagnostics.