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Cellular synchronization in organs like the heart is vital. This study reveals how intercellular coupling and mechanical forces create coordinated activity, crucial for physiological function.

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Area of Science:

  • Physiology
  • Biophysics
  • Computational Biology

Background:

  • Synchronization of myocyte activity is essential for vital organ function, such as in the heart.
  • Understanding self-organized coordination in heterogeneous excitable cell ensembles is clinically significant.

Purpose of the Study:

  • To investigate the collective behavior of excitable cells under varying intercellular coupling and electrophysiological diversity.
  • To explore the role of stretch-activated currents in promoting global coherence.

Main Methods:

  • Computational modeling of excitable cell ensembles.
  • Systematic variation of intercellular coupling strength.
  • Analysis of electrophysiological diversity and its impact on collective dynamics.
  • Inclusion of stretch-activated currents to simulate mechanical feedback.

Main Results:

  • A wide spectrum of collective behaviors emerged with altered coupling and diversity, including synchronized activity clusters.
  • Stretch-activated currents were shown to modulate cellular activity through mechanical deformation waves.
  • Mechanical feedback significantly promoted robust global coherence in the cell ensemble.

Conclusions:

  • Intercellular coupling and cellular diversity are key determinants of collective dynamics in myocyte systems.
  • Mechanical feedback via stretch-activated currents is a critical mechanism for achieving robust global synchronization.
  • Findings have implications for understanding and potentially treating cardiac arrhythmias and other synchronization-related disorders.