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  11. The Effect Of Dexamethasone On Reducing The Frequency Of Endotracheal Intubation And Mechanical Ventilation Required In Children With Acute Laryngitis And Laryngeal Obstruction

The effect of dexamethasone on reducing the frequency of endotracheal intubation and mechanical ventilation required in children with acute laryngitis and laryngeal obstruction

Lv Yan1, Jiali Wu1, Kai Shi1

  • 1Emergency Department of Jiangxi Children's Hospital Nanchang, Jiangxi, China.

Pakistan Journal of Pharmaceutical Sciences
|January 3, 2026

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View abstract on PubMed

Summary
This summary is machine-generated.

Pediatric acute laryngitis often requires intubation despite dexamethasone treatment. Female gender, comorbidities, high neutrophil-to-lymphocyte ratio, and elevated IgM levels are key risk factors for intubation in these children.

Area of Science:

  • Pediatric Emergency Medicine
  • Pediatric Critical Care
  • Otolaryngology

Background:

  • Acute laryngitis and laryngeal obstruction in children can be severe, necessitating airway intubation.
  • Dexamethasone is a common treatment, but factors predicting intubation despite its use are not well understood.

Purpose of the Study:

  • To determine the rate of intubation and mechanical ventilation in pediatric patients with acute laryngitis and laryngeal obstruction.
  • To identify risk factors for intubation despite dexamethasone therapy.
  • To examine outcomes in intubated pediatric patients receiving dexamethasone.

Main Methods:

  • A cross-sectional study at Jiangxi Children's Hospital included 150 pediatric patients treated with dexamethasone.
  • Patients were stratified into intubated and non-intubated groups.
Keywords:
Acute laryngitisChildrenCross-sectional studyDexamethasone

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  • Multiple logistic regression analysis identified risk factors for intubation.

    • Main Results:

    • 18.75% of patients required intubation.
    • Independent risk factors for intubation included female gender (OR=4.07), comorbidities (OR=7.30), increased neutrophil-to-lymphocyte ratio (OR=1.167), and elevated IgM (OR=1.221).
    • These factors were significant predictors for intubation need despite steroid therapy.

    Conclusions:

    • The intubation rate for pediatric acute laryngitis remains high, even with dexamethasone.
    • Identifying female gender, comorbidities, neutrophil-to-lymphocyte ratio, and high IgM levels aids in early diagnosis and management.
    • These risk factors can guide clinical decisions for pediatric patients with laryngeal obstruction.
    Laryngeal obstruction
    Mechanical ventilation
    Risk factors