Intraocular Lens Opacification in a Patient With Gyrate Atrophy With a Subluxated Intraocular Lens
Yazeed A Alferayan1, Sami T Hameed1, Azza M Y Maktabi2
1Anterior Segment Division, King Khaled Eye Specialist Hospital, Riyadh, Saudi Arabia.
The American Journal of Case Reports
|January 3, 2026
Summary
Gyrate atrophy patients may develop unique, rosette-shaped intraocular lens opacities after cataract surgery. This calcium oxalate deposit pattern highlights the need for vigilant post-operative monitoring in these individuals.
Area of Science:
- Ophthalmology
- Medical Genetics
- Metabolic Diseases
Background:
- Gyrate atrophy is a rare metabolic disorder affecting the choroid and retina.
- Ocular complications include cataracts and zonular issues, often requiring cataract surgery.
- Intraocular lens (IOL) opacification is a known post-surgical complication, but specific patterns in gyrate atrophy are undocumented.
Purpose of the Study:
- To report a novel pattern of IOL opacification in a patient with gyrate atrophy.
- To investigate the composition of the opacities.
- To propose a potential link between gyrate atrophy and this specific IOL complication.
Main Methods:
- Case report of a 37-year-old man with gyrate atrophy.
- Description of visual decline, IOL subluxation, and rosette-shaped opacities.
- Surgical removal of IOL, insertion of scleral-tucked IOL, and anterior vitrectomy.
- Microscopic and histopathological analysis of removed IOL material.
Main Results:
- The patient developed late IOL subluxation and distinctive rosette-shaped opacities.
- Histopathology revealed crystalline deposits consistent with calcium oxalate.
- These deposits stained positive with von Kossa stain and showed birefringence.
Conclusions:
- This is the first reported case of calcium oxalate IOL opacities in a patient with gyrate atrophy.
- Regular monitoring of gyrate atrophy patients post-cataract surgery is crucial.
- A potential pathophysiological mechanism linking gyrate atrophy to this IOL complication is proposed.
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