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Related Experiment Video

Updated: May 5, 2026

Synthesis of Multi-walled Carbon Nanotubes Modified with Silver Nanoparticles and Evaluation of Their Antibacterial Activities and Cytotoxic Properties
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Multifunctional POSS-based nanoparticles functionalized with silver, SPIONs, and rhamnolipid for antibacterial

Güneş Kibar1, Melisa Kafali2, Olgu Cagan Ozonuk2

  • 1Micro Nano Particles (MNP) Research Group, Materials Science and Engineering Department, Adana Alparslan Turkes Science and Technology University, Adana, 01250, Türkiye; Dpt of Medical Biology, Faculty of Medicine, Atilim Uni, 06830, Ankara, Türkiye; Center for Engineering in Medicine and Surgery, Massachusetts General Hospital, Harvard Medical School, Boston, MA, 02114, USA; Shriners Hospitals for Children, Boston, MA, 02114, USA.

Biomaterials Advances
|January 3, 2026
PubMed
Summary

Novel nanoparticles combining silver, iron oxide, and rhamnolipid with POSS show potent antibacterial and antibiofilm activity. These magnetically targeted agents are effective against S. aureus and P. aeruginosa, with good cytocompatibility for biomedical applications.

Keywords:
AntibacterialAntibiofilmOsteoblastPolydopaminePolyhedral oligomeric silsesquioxane (POSS)RhamnolipidSilver nanoparticlesSuperparamagnetic iron oxide (SPION)

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Area of Science:

  • Nanotechnology
  • Materials Science
  • Biomedical Engineering

Background:

  • Nano-engineered materials with bio-based modifications show promise against bacterial infections.
  • Polyhedral oligomeric silsesquioxane (POSS) nanoparticles offer a versatile platform for functionalization.

Purpose of the Study:

  • To synthesize and evaluate the antibacterial and antibiofilm properties of POSS nanoparticles functionalized with silver nanoparticles (Ag), superparamagnetic iron oxide nanoparticles (SPIONs), and rhamnolipid (RL).
  • To assess the potential of these nanoparticles for magnetically targeted drug delivery and management of bacterial infections, particularly orthopedic infections.

Main Methods:

  • POSS nanoparticles were functionalized with Ag, SPIONs, and RL individually and in combination.
  • Antibacterial and antibiofilm activities were tested against Staphylococcus aureus and Pseudomonas aeruginosa.
  • Nanoparticle size, superparamagnetic behavior, and cytocompatibility with human osteoblasts were evaluated.

Main Results:

  • Functionalized nanoparticles ranged from 127 to 227 nm and exhibited superparamagnetic properties.
  • RL-coated, Ag- and SPION-decorated POSS nanoparticles (RSMP) showed the highest efficacy, reducing S. aureus and P. aeruginosa growth by ~90% and ~66% at 0.01 g/L.
  • RSMP demonstrated significant biofilm inhibition, low MIC50 values, and supported osteoblast proliferation up to 0.05 g/L.

Conclusions:

  • RSMP nanoparticles represent a promising platform for magnetically targetable antibacterial agents.
  • These nanoparticles exhibit potent antibacterial and antibiofilm activities with favorable cytocompatibility.
  • Potential applications include the management of orthopedic infections and other biomedical uses.