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Updated: Jan 7, 2026

A Silicosis Mouse Model Established by Repeated Inhalation of Crystalline Silica Dust
Published on: January 6, 2023
[Meta-analysis of influencing factors on the progression of pneumoconiosis]
1School of Public Health, University of South China, Hengyang 421001, China Department of Scientific Research and Teaching, Hunan Prevention and Treatment Institute for Occupational Diseases (Affiliated Prevention and Treatment Institute for Occupational Diseases of University of South China), Changsha 410007, China.
Abstract:
Objective: Meta-analysis was performed to determine the influencing factors on the progression of pneumoconiosis, providing a basis for optimizing prevention and treatment strategies for pneumoconiosis. Methods: The research date was from April 10(th), 2025 to May 5(th), 2025, PubMed, Embase, Web of Science, CNKI, VIP Chinese Science and Technology Journal Database, Wanfang and other Chinese and English databases were searched, and the search time was from the establishment of the database to April 19(th), 2025. A combined search method of subject terms and free terms was adopted to collect research on the influencing factors of the progression of pneumoconiosis. Based on the results of the heterogeneity test, a fixed-effect model or a random-effect model was selected for analysis, and the sources of heterogeneity were explored through subgroup analysis. Results: Sixteen articles were included, encompassing 20 related risk factors. Meta-analysis results showed that the stage of pneumoconiosis (OR=2.85, 95%CI=2.15-3.77), duration of dust exposure (OR=1.77, 95%CI=1.34-2.33), smoking (OR=2.47, 95%CI=1.40-4.35), comorbidities (OR=1.73, 95%CI=1.35-2.21), age at onset (OR=1.78, 95%CI=1.21-2.61), and protective measures (OR=0.74, 95%CI=0.63-0.86) were all influencing factors for the progression of pneumoconiosis (P<0.05). Body mass index and age were not significantly associated with the progression of pneumoconiosis (P>0.05) . Conclusion: The influencing factors of pneumoconiosis progression include smoking history, stage of pneumoconiosis, duration of dust exposure, comorbidities, age at onset, protective measures. Among them, stage of pneumoconiosis showing the strongest association with the progression of pneumoconiosis.
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