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Grounded report generation for enhancing ophthalmic ultrasound interpretation using Vision-Language Segmentation
Kai Jin1,2, Qixuan Sun3, Daohuan Kang4
1Eye Center of Second Affiliated Hospital, School of Medicine, Zhejiang University, Hangzhou, China. jinkai@zju.edu.cn.
NPJ Digital Medicine
|January 4, 2026
Summary
A new AI model, Vision-Language Segmentation (VLS), accurately interprets ophthalmic ultrasound images, improving diagnostic speed and reducing costs. This AI enhances efficiency for eye condition diagnosis using ultrasound data.
Area of Science:
- Ophthalmology
- Artificial Intelligence
- Medical Imaging
Background:
- Ophthalmic ultrasound interpretation is vital but requires expertise and time.
- Increasing ultrasound data necessitates efficient AI solutions for analysis and reporting.
- Existing AI models lack lesion identification and interpretability.
Purpose of the Study:
- To introduce the Vision-Language Segmentation (VLS) model for ophthalmic ultrasound interpretation.
- To enhance diagnostic accuracy and interpretability in AI-driven ultrasound analysis.
- To evaluate the VLS model's performance and cost-effectiveness.
Main Methods:
- Developed the VLS model by integrating a Vision-Language Model (VLM) with the Segment Anything Model (SAM).
- Trained and tested the model on 64,098 images and 21,355 reports from three hospitals.
- Evaluated performance using BLEU4 scores, dice coefficients, specificity, and diagnostic accuracy.
Main Results:
- Achieved high BLEU4 scores (66.37 internal, 85.36/73.77 external) and dice coefficients (59.6% internal, 50.2%/51.5% external).
- Demonstrated strong diagnostic accuracy (90.59% internal, 71.87% external) with high specificity (97.8%/97.7%).
- Showcased a 30-fold cost reduction in report generation, from $39 to $1.3 per report.
Conclusions:
- The VLS model offers an interpretable and accurate solution for ophthalmic ultrasound analysis.
- This AI approach significantly reduces manual effort and accelerates diagnostic workflows.
- VLS presents a promising advancement for efficient and cost-effective ophthalmic diagnostics.

