Kawasaki Disease in Infancy and Long-Term Body Mass Index Trajectories
These videos have been matched automatically. Contact us if they are not relevant.
These videos have been matched automatically. Contact us if they are not relevant.
View abstract on PubMed
Summary
This summary is machine-generated.A history of Kawasaki disease (KD) in infancy did not impact long-term body mass index (BMI) trajectories through early adolescence. This study found no association between childhood KD and later BMI patterns.
Area Of Science
- Pediatrics
- Cardiovascular Health
- Growth and Development
Background
- Kawasaki disease (KD) is linked to long-term cardiovascular risks, prompting concerns about potential future obesity.
- Limited longitudinal data exist on body mass index (BMI) trajectories in children with a history of KD.
- Understanding these trajectories is crucial for assessing long-term health outcomes post-KD.
Purpose Of The Study
- To investigate the long-term body mass index (BMI) z-score trajectories in children with a history of Kawasaki disease (KD) from infancy to early adolescence.
- To determine if a history of KD influences the patterns of BMI changes over time.
- To provide insights into the cardiovascular health risks associated with KD by examining BMI development.
Main Methods
- A secondary analysis was performed on a large, nationwide Japanese birth cohort of 19,642 children followed for 13 years.
- Exposure was defined as parent-reported hospitalization for Kawasaki disease (KD) between 6 and 18 months of age.
- Group-based multivariate trajectory modeling was used to identify distinct BMI z-score trajectory groups.
Main Results
- Three distinct BMI z-score trajectories were identified: "Stable," "High-Decreasing," and "Low-Increasing."
- Multivariable adjustment revealed no significant association between a history of Kawasaki disease (KD) and membership in any of these BMI trajectory groups for both males and females.
- Infancy KD history did not predict different long-term BMI patterns.
Conclusions
- A history of Kawasaki disease (KD) in infancy is not associated with altered long-term BMI trajectories up to early adolescence.
- These findings suggest that KD may not significantly impact overall BMI development during childhood and early adolescence.
- Further research may explore other long-term health outcomes related to cardiovascular health in KD survivors.
These videos have been matched automatically. Contact us if they are not relevant.
These videos have been matched automatically. Contact us if they are not relevant.
Related Concept Videos
Drug distribution in the pediatric population exhibits unique challenges and considerations due to the physiological differences between children, particularly neonates and infants, and adults. A crucial aspect of pediatric pharmacology is understanding how these differences impact the pharmacokinetics of various drugs, necessitating age-specific dosing strategies to ensure efficacy and safety.Neonates and infants have a higher total body water content, ~75%–90% of their body weight,...
In pediatric care, understanding the nuances of hepatic drug metabolism is crucial, as it significantly differs from that of adults. This divergence is primarily due to the developmental stage of drug-metabolizing enzymes, which affects how medications are processed in the body. In neonates, for instance, the activity of Phase I enzymes—critical for the initial breakdown of drugs—is markedly reduced, functioning at just 20–40% of the levels seen in adults. This reduction poses...
The Body Mass Index (BMI) is a numerical value derived from a person's weight and height, used to categorize individuals into weight ranges. It is calculated using the formula: weight in kilograms divided by height in meters squared. Obesity is a health condition characterized by excessive accumulation of adipose tissue that poses health risks, often diagnosed with a BMI ≥ 30. This excess fat storage occurs when surplus dietary calories are converted into triglycerides and stored in...
Understanding the physiological differences in the pediatric population is crucial for effective pharmacotherapy. Neonates, infants, and children exhibit significant variations in gastric pH, gastric emptying time, intestinal transit time, and biliary function. These variations profoundly affect oral drug absorption, necessitating a nuanced approach to pediatric dosing.Neonates present with a unique physiological profile, having a gastric pH greater than 4 and faster and more irregular gastric...
Proteins are broken down into amino acids during digestion. Unlike fats and carbohydrates, which are stored for later use, proteins are not. Instead, amino acids are either used to produce ATP through oxidation or contribute to the creation of new proteins for the growth and repair of the body. Any surplus amino acids from the diet are converted into glucose or triglycerides rather than excreted.
Amino acids play various roles in the body once they are absorbed into cells. They are restructured...
In pediatric medicine, understanding the renal function and drug elimination nuances is crucial for administering safe and effective treatments. Newborns, in particular, display markedly slower renal functions than adults, profoundly affecting how drugs are cleared from their bodies. This slower drug clearance requires clinicians to extend the dosing intervals for many medications to prevent drug accumulation and toxicity while ensuring therapeutic efficacy.One key area where these adjustments...