Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Vaccinations01:51

Vaccinations

51.1K
Overview
51.1K
Types of Biopharmaceutical Studies: Controlled and Non-Controlled Approaches01:23

Types of Biopharmaceutical Studies: Controlled and Non-Controlled Approaches

376
Biopharmaceutical studies constitute a vital field aiming to enhance drug delivery methods and refine therapeutic approaches, drawing upon diverse interdisciplinary knowledge. In research methodologies, the choice between controlled and non-controlled studies significantly influences the study's reliability and accuracy.
Non-controlled studies, commonly employed for initial exploration, lack a control group, rendering them susceptible to biases and external influences. In contrast,...
376
Determination of Multiple Dosing Parameters: Loading and Maintenance Doses01:25

Determination of Multiple Dosing Parameters: Loading and Maintenance Doses

194
A loading dose is an essential pharmacological strategy to rapidly achieve the target plasma drug concentration necessary for an immediate therapeutic effect. This approach is especially critical for drugs characterized by slow absorption or extended half-lives, where delaying therapeutic plasma levels could compromise treatment outcomes. By administering a loading dose, clinicians ensure a prompt onset of drug action, even for agents with complex pharmacokinetic profiles.Achieving steady-state...
194

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Impact of Implementing Alternative Human Papillomavirus (HPV) Vaccination Strategies in Kenya: A Modeling Study.

MDM policy & practice·2026
Same author

Approximating vaccine delivery costs to reach zero-dose children: a Bayesian meta-regression analysis.

Health policy and planning·2026
Same author

HPV vaccination and early declines in cervical cancer deaths.

Lancet (London, England)·2026
Same author

The economic burden of respiratory syncytial virus and other acute respiratory infections among children <2 years old seeking care at a tertiary facility in Accra, Ghana.

Journal of global health·2026
Same author

Quantifying relative health impact across Gavi, the Vaccine Alliance's portfolio in 117 countries at the subregional level: a modelling study.

Lancet (London, England)·2026
Same author

Impact and cost-effectiveness of two interventions to prevent paediatric respiratory syncytial virus disease in Cameroon: a modelling approach.

Journal of global health·2026

Related Experiment Video

Updated: Jan 7, 2026

Author Spotlight: Advancing Biotherapeutic Mass Calculation by Introducing mAbScale, a Python-Based Desktop Application
04:24

Author Spotlight: Advancing Biotherapeutic Mass Calculation by Introducing mAbScale, a Python-Based Desktop Application

Published on: June 16, 2023

2.2K

Estimating the Value of Combination Vaccines: A Methodological Framework.

Mark Jit1, Allison Portnoy2, Clint Pecenka3

  • 1Department of Global and Environmental Health, School of Global Public Health, New York University, New York, NY, USA. mark.jit@nyu.edu.

Pharmacoeconomics
|January 4, 2026
PubMed
Summary
This summary is machine-generated.

Combination vaccines offer public health benefits but require economic evaluation. A new framework captures their value through caregiver cost savings, system efficiencies, and streamlined schedules.

More Related Videos

Author Spotlight: Optimizing CFU Determination for Efficient Assessment of TB Vaccine Efficacy and Antigen Presentation Analysis
06:26

Author Spotlight: Optimizing CFU Determination for Efficient Assessment of TB Vaccine Efficacy and Antigen Presentation Analysis

Published on: July 28, 2023

2.9K
Whole-animal Imaging and Flow Cytometric Techniques for Analysis of Antigen-specific CD8+ T Cell Responses after Nanoparticle Vaccination
11:07

Whole-animal Imaging and Flow Cytometric Techniques for Analysis of Antigen-specific CD8+ T Cell Responses after Nanoparticle Vaccination

Published on: April 29, 2015

13.7K

Related Experiment Videos

Last Updated: Jan 7, 2026

Author Spotlight: Advancing Biotherapeutic Mass Calculation by Introducing mAbScale, a Python-Based Desktop Application
04:24

Author Spotlight: Advancing Biotherapeutic Mass Calculation by Introducing mAbScale, a Python-Based Desktop Application

Published on: June 16, 2023

2.2K
Author Spotlight: Optimizing CFU Determination for Efficient Assessment of TB Vaccine Efficacy and Antigen Presentation Analysis
06:26

Author Spotlight: Optimizing CFU Determination for Efficient Assessment of TB Vaccine Efficacy and Antigen Presentation Analysis

Published on: July 28, 2023

2.9K
Whole-animal Imaging and Flow Cytometric Techniques for Analysis of Antigen-specific CD8+ T Cell Responses after Nanoparticle Vaccination
11:07

Whole-animal Imaging and Flow Cytometric Techniques for Analysis of Antigen-specific CD8+ T Cell Responses after Nanoparticle Vaccination

Published on: April 29, 2015

13.7K

Area of Science:

  • Vaccinology
  • Health Economics
  • Public Health Policy

Background:

  • Combination vaccines integrate multiple antigens into a single administration, offering programmatic advantages for crowded immunization schedules.
  • Despite benefits, higher development costs and unclear market signals can deter manufacturer investment in combination vaccines.
  • Existing health economic evaluation frameworks may not fully capture the multifaceted value of combination vaccines.

Purpose of the Study:

  • To propose a comprehensive framework for evaluating the economic value of combination vaccines.
  • To demonstrate how this framework can inform investment decisions for new vaccine introductions.
  • To highlight the need for data collection to support real-world application of the framework.

Main Methods:

  • Developed a four-domain framework to capture the value of combination vaccines: caregiver cost reductions, health system operational efficiencies, opportunity costs of schedule slots, and schedule streamlining.
  • Applied the framework to a hypothetical vaccine introduction scenario, comparing standalone, replacement, and combination product formulations.
  • Considered the value of reducing administrations for standalone vaccines.

Main Results:

  • The proposed framework quantifies benefits beyond direct medical costs, including tangible/intangible caregiver costs and health system efficiencies.
  • Comparing introduction scenarios revealed distinct value propositions for standalone versus combination vaccine products.
  • The framework's practicality was demonstrated through a hypothetical case study.

Conclusions:

  • A comprehensive economic evaluation framework is crucial for accurately assessing the value of combination vaccines.
  • Capturing caregiver savings, operational efficiencies, and schedule benefits is essential for guiding vaccine investment decisions.
  • Further data collection on existing vaccine values and willingness-to-pay for fewer administrations will enhance framework application.