Relationship Between Fibrinogen-to-Albumin Ratio and Pre-Eclampsia: A Retrospective Cohort Study

Area of Science:

• Obstetrics and Gynecology
• Clinical Chemistry
• Maternal-Fetal Medicine

Background:

• Preeclampsia poses significant risks to maternal and fetal health globally.
• Limited availability of cost-effective biomarkers for preeclampsia necessitates further research.
• The fibrinogen-to-albumin ratio (FAR) shows potential as an inflammatory marker but requires validation in diverse populations.

Purpose of the Study:

• To investigate the association between the fibrinogen-to-albumin ratio (FAR) and preeclampsia.
• To evaluate the discriminatory performance of FAR in identifying preeclampsia.
• To assess the independent predictive value of FAR for preeclampsia in a large cohort.

Main Methods:

• Retrospective cohort analysis of 3,249 patients delivering between March 2018 and February 2024.
• Patients classified into control, preeclampsia (PE), and severe preeclampsia (sPE) groups.
• Univariate, multivariate analyses, and ROC curve analysis used to assess FAR's association and discriminatory power.

Main Results:

• FAR was significantly elevated in both PE and sPE groups compared to controls.
• Univariate analysis revealed strong associations between FAR and any PE, and sPE.
• Multivariate analysis confirmed FAR as an independent predictor for PE, though not for sPE.

Conclusions:

• The fibrinogen-to-albumin ratio (FAR) is independently associated with preeclampsia.
• FAR may aid clinicians in risk stratification and perioperative planning upon labor admission.
• Further validation through prospective, multicenter studies is recommended.