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Author Spotlight: Advancing Research on Candida albicans Biofilm-Associated Prosthetic Joint Infections

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Intracranial Candida Auris Infection: A Case Report and Scoping Review.

Gabriel L Jelkin¹, Allie L Heineman¹, Henry T Beckett¹

¹Department of Neurological Surgery, University of Cincinnati College of Medicine, Cincinnati, Ohio, USA.

World Neurosurgery

|January 4, 2026

Summary

This summary is machine-generated.

Candida auris central nervous system (CNS) infections are rare but serious. Early diagnosis and combination therapy targeting both systemic and CNS compartments are crucial for better patient outcomes.

Keywords:

Antifungal therapy Candida auris Central nervous system infections Meningitis Neurosurgical complications Scoping review

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Area of Science:

Infectious Diseases
Neuroscience
Medical Mycology

Background:

Candida auris (C. auris) is a multidrug-resistant yeast.
C. auris causes invasive infections, with CNS involvement being rare and poorly understood.
This study addresses the diagnostic and therapeutic challenges of C. auris CNS infections.

Purpose of the Study:

To present a case of C. auris CNS infection.
To conduct a scoping review of adult C. auris CNS infection cases.
To identify trends in diagnosis and treatment of C. auris CNS infections.

Main Methods:

Searched multiple databases (PubMed, Embase, Scopus, Web of Science, Europe PMC) from 2009-2025.
Included nine publications describing eleven adult cases of C. auris CNS infection.
Extracted data on clinical presentation, diagnostics, therapy, surgical intervention, and outcomes.

Main Results:

Patients presented with fever, headache, altered mental status, focal deficits, or hydrocephalus.
Diagnosis involved culture, molecular methods, or clinical suspicion; CSF showed pleocytosis, elevated protein, and hypoglycorrhachia.
Liposomal amphotericin B with flucytosine or echinocandins was common; echinandin monotherapy was ineffective. Intrathecal echinocandins and systemic flucytosine showed promise.

Conclusions:

Neurosurgical devices increase CNS C. auris risk.
Rapid diagnostics and susceptibility-guided therapy are essential.
Combined systemic and CNS treatment, along with device management, may improve outcomes.
Standardized protocols and further research are needed for this emerging pathogen.