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Related Experiment Video

Updated: Jan 7, 2026

Biventricular Assessment of Cardiac Function and Pressure-Volume Loops by Closed-Chest Catheterization in Mice

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Impact of Left Ventricular Diastolic Function on Right Ventricular Size and Function.

Muhammad U Almani¹, Ardel J Romero², Emmanuel Akuna¹

¹Division of Cardiology, Jefferson Einstein Philadelphia Hospital, Thomas Jefferson University, Philadelphia, Pennsylvania.

Journal of the American Society of Echocardiography : Official Publication of the American Society of Echocardiography

|January 4, 2026

Summary

Left ventricular diastolic dysfunction (DD) is linked to changes in right ventricular (RV) size and function. Even mild DD (grade 1) significantly impacts RV ejection fraction (RVEF) and atrial strain.

Keywords:

3-Dimensional echocardiography Left ventricular diastolic function Right ventricular ejection fraction Right ventricular volume

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Last Updated: Jan 7, 2026

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Published on: April 27, 2019

Area of Science:

Cardiology
Echocardiography
Cardiac Physiology

Background:

Left ventricular diastolic dysfunction (DD) is prevalent and can lead to heart failure with preserved ejection fraction (HFpEF).
While right ventricular (RV) dilation and dysfunction are recognized in severe HFpEF, the impact of lesser degrees of DD on RV parameters is less understood.

Purpose of the Study:

To investigate the association between varying grades of left ventricular (LV) diastolic dysfunction and right ventricular (RV) size and function.
To explore the effects of early-stage DD on RV volumes, ejection fraction, and atrial function.

Main Methods:

Utilized 3-dimensional echocardiography in 370 patients to assess RV volumes, ejection fraction, and strain.
Graded LV diastolic function using the 2025 ASE algorithm.
Compared RV measurements across different diastolic function groups, controlling for clinical confounders.

Main Results:

Right ventricular end-diastolic volume (RVEDV) and indexed RVEDV increased significantly with worsening DD grades (p<0.0001).
RV ejection fraction (RVEF) showed a significant, graded decrease across diastolic function groups, even with grade 1 DD (p < 0.0003).
Atrial reservoir strain decreased in grade 1 DD compared to normal, despite similar indexed atrial volumes.

Conclusions:

LV diastolic function is significantly associated with RVEDV and RVEF.
Even mild (grade 1) DD leads to a statistically significant reduction in RVEF.
Reduced atrial strain, particularly reservoir strain, is observed in early DD, suggesting subtle functional impairment.