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Imaging evidence of diabetic pancreatopathy: An exploratory IVIM MRI study

Boyu Liu1, Feng Huang1, Peng Liu1

  • 1Department of Radiology, Hunan Provincial People's Hospital, First Affiliated Hospital of Hunan Normal University, Changsha 410005, China.

Magnetic Resonance Imaging
|January 4, 2026
PubMed
Abstract

Insights

Intravoxel Incoherent Motion (IVIM) MRI reveals distinct pancreatic changes in type 2 diabetes mellitus (T2DM). T2DM shows altered perfusion in the pancreatic head and microstructural damage in the tail, correlating with disease duration.

Area of Science:

  • Radiology and Imaging
  • Endocrinology and Metabolism
  • Medical Diagnostics

Background:

  • Type 2 Diabetes Mellitus (T2DM) is associated with pancreatic microstructural alterations.
  • Understanding these changes is crucial for managing diabetic complications.

Purpose of the Study:

  • To investigate pancreatic microstructural alterations in T2DM using Intravoxel Incoherent Motion (IVIM) MRI.
  • To identify potential imaging biomarkers for diabetic pancreatic injury.

Main Methods:

  • A cross-sectional study involving 152 participants (72 T2DM, 80 controls).
  • Quantification of IVIM-derived parameters (perfusion fraction F, diffusion coefficient D) in the pancreatic head, body, and tail.
  • Statistical analysis using multivariable logistic regression and Pearson's correlation.

Main Results:

  • T2DM patients showed significantly elevated perfusion fraction (F) in the pancreatic head.
  • A reduced pure diffusion coefficient (Dp) was observed in the pancreatic tail, indicating microstructural damage.
  • Pancreatic tail F positively correlated with T2DM duration, while tail Dp negatively correlated.

Conclusions:

  • IVIM MRI suggests spatial heterogeneity in diabetic pancreatopathy.
  • Compensatory perfusion changes in the pancreatic head and progressive microstructural alterations in the tail were observed.
  • Pancreatic tail IVIM parameters, especially F, may serve as imaging biomarkers for diabetic pancreatic injury.
Keywords:
Diabetic pancreatopathyImaging biomarkersIntravoxel incoherent motion diffusion-weighted imagingType 2 diabetes mellitus

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