Related Experiment Video
Updated: Apr 30, 2026

06:54
Ex Vivo Perfusion of the Rodent Placenta
Published on: May 30, 2019
10.4K
Cesarean delivery for placenta previa.
Ottavio Cassardo1, Michele Orsi1, Manuela Wally Ossola1
1Division of Obstetrics, Fondazione IRCCS Ca' Granda Ospedale Maggiore Policlinico, Milan, Italy.
American Journal of Obstetrics and Gynecology
|January 4, 2026
Summary
Placenta previa, a condition requiring cesarean delivery, poses significant risks for mothers and newborns, including hemorrhage and preterm birth. Management balances maternal safety with fetal development, guiding delivery timing and surgical preparedness.
Area of Science:
- Obstetrics and Gynecology
- Maternal-Fetal Medicine
- Reproductive Health
Background:
- Placenta previa affects 0.5%–1% of deliveries, a significant decrease from mid-trimester scans (up to 10%).
- Risk factors include prior cesarean delivery (4%–8% recurrence), twin gestations, and assisted reproduction (6-fold increased risk).
- Maternal morbidity is characterized by hemorrhage (40%–60% antepartum, 20%–35% postpartum), and neonatal risk is driven by preterm birth (over 40% before 37 weeks).
Purpose of the Study:
- To review the diagnosis, management, and outcomes of placenta previa.
- To highlight the risks associated with placenta previa for both maternal and neonatal health.
- To provide guidance on antenatal management and delivery planning.
Main Methods:
- Diagnosis relies on transvaginal ultrasound as the gold standard, confirming transabdominal findings and assessing internal os distance.
- Management strategies balance the risk of maternal hemorrhage against the risks of iatrogenic prematurity.
- Delivery planning considers asymptomatic previa (scheduled cesarean at 36–37.6 weeks) and low-lying placenta (trial of labor with internal os distance of 11–20 mm).
Main Results:
- Placenta previa is a leading indication for preterm delivery before 35 weeks (6%–7%).
- Multidisciplinary team approach and preparedness for hemorrhage are crucial for operative care.
- Postpartum support and debriefing are recommended due to the psychological burden.
Conclusions:
- Effective management of placenta previa requires a multidisciplinary team and careful consideration of delivery timing.
- Transvaginal ultrasound is essential for accurate diagnosis and exclusion of associated conditions like placenta accreta spectrum and vasa previa.
- Preparedness for major hemorrhage and structured postpartum support are vital components of care.
Related Concept Videos
Teratogenicity
4.2K
The ability of a drug to produce structural deformations and functional abnormalities in the developing embryo or the fetus is called teratogenicity, and the drug producing this effect is known as a teratogen. Teratogenic effects include stillbirth, miscarriage, intrauterine growth restriction, and neurocognitive delay. A teratogen may affect the embryo at different stages of development, which is important in determining the type and extent of the damage. During blastocyst formation, the early...
4.2K
Mitral Valve Prolapse III: Nursing Management
586
The nursing management of Mitral Valve Prolapse, or MVP, centers around patient education, symptom monitoring, and lifestyle modifications.Patient Education on MVP Diagnosis and Heredity: Nurses should provide comprehensive education about MVP, a condition where the mitral valve does not close appropriately during heartbeats. This education often includes the condition's pathophysiology, symptoms, and potential complications, like arrhythmias or mitral regurgitation. Though not fully...
586

