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Related Concept Videos

Drug Distribution: Tissue Binding01:21

Drug Distribution: Tissue Binding

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Upon entering the systemic circulation, drugs can distribute into the interstitial and intracellular fluid of various tissue cells. This distribution is facilitated by the binding of drugs to different cellular components within tissues, which may lead to drug accumulation in specific areas. Drugs bound to tissue components serve as reservoirs that release free drugs back into the system, prolonging the drug's overall action. However, this accumulation can also result in local toxicity.
For...
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Asymmetric Lipid Bilayer01:35

Asymmetric Lipid Bilayer

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Biological membranes show uneven distribution of different types of lipids in the inner and outer layers, resulting in transverse asymmetric membranes. The treatment of the erythrocyte membrane with the enzyme phospholipase confirmed the asymmetric nature of the lipid bilayer. The enzyme hydrolyzes lipids into fatty acids and hydrophilic groups. The phospholipase acts only on the outer layer of the membrane, while the inner layer remains intact. The phospholipase treatment resulted in 80%...
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Factors Affecting Drug Distribution: Organ Perfusion Rate01:15

Factors Affecting Drug Distribution: Organ Perfusion Rate

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Drug distribution within the body is a complex process influenced by several factors, including perfusion rate, the rate at which the bloodstream transports drugs to tissue. This limitation becomes particularly significant when dealing with highly lipophilic drugs. In such cases, the rate at which the drug can move across membranes is crucial, and if the membrane is highly permeable to the drug, distribution becomes rate-limited by perfusion.
Perfusion rate-limited distribution relies on the...
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Pharmacokinetics in Pediatric Patients: Drug Distribution01:17

Pharmacokinetics in Pediatric Patients: Drug Distribution

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Drug distribution in the pediatric population exhibits unique challenges and considerations due to the physiological differences between children, particularly neonates and infants, and adults. A crucial aspect of pediatric pharmacology is understanding how these differences impact the pharmacokinetics of various drugs, necessitating age-specific dosing strategies to ensure efficacy and safety.Neonates and infants have a higher total body water content, ~75%–90% of their body weight,...
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Factors Affecting Drug Distribution: Tissue Permeability01:30

Factors Affecting Drug Distribution: Tissue Permeability

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The drug distribution process within the human body is a complex interplay of various physicochemical properties inherent to the drugs. These properties, including molecular size, ionization degree, partition coefficient, and stereochemical nature, significantly impact how drugs permeate biological membranes to reach their target tissues.
Small molecules with a molecular weight below 500 to 600 Daltons can easily pass through the capillary membrane, gaining access to different tissues. Larger...
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Membrane Lipids01:32

Membrane Lipids

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Lipids are an essential component of all biological membranes. The average lipid content in mammalian membranes is 50%, though it can be as low as 20% in the inner mitochondrial membrane or as high as 80% in the myelin sheath present around the nerve cells.
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Related Experiment Video

Updated: Jan 7, 2026

Preparation, Administration, and Assessment of In Vivo Tissue-Specific Cellular Uptake of Fluorescent Dye-Labeled Liposomes
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Preparation, Administration, and Assessment of In Vivo Tissue-Specific Cellular Uptake of Fluorescent Dye-Labeled Liposomes

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Distinct Composition-dependent Biodis-tribution Patterns of Phospholipid Liposomes.

Takahito Kawano1, Jeong-Hun Kang2, Masaharu Murata1,3

  • 1Center for Advanced Medical Innovation, Kyushu University, 3-1-1 Maidashi, Higashi-ku, Fukuoka 812-8582, JAPAN.

Journal of Oleo Science
|January 4, 2026
PubMed
Summary
This summary is machine-generated.

Phosphatidylserine (PS) and phosphatidylethanolamine (PE) liposomes biodistribution varies. DOPC/DOPS liposomes showed higher organ accumulation than DOPC/DOPE, indicating phospholipid composition impacts liposome distribution.

Keywords:
anionic liposomeanti-inflammationbiodistributionphospholipidtissue

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A Liposome Membrane Permeability Assay for Investigating the Effects of Phosphatidylinositol Phosphate Groups on Membranotropic Action of Venom PLA2
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Fluorescence-Based Measurements of Phosphatidylserine/Phosphatidylinositol 4-Phosphate Exchange Between Membranes
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Fluorescence-Based Measurements of Phosphatidylserine/Phosphatidylinositol 4-Phosphate Exchange Between Membranes
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Fluorescence-Based Measurements of Phosphatidylserine/Phosphatidylinositol 4-Phosphate Exchange Between Membranes

Published on: March 14, 2021

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Area of Science:

  • Biomedical science
  • Lipidomics
  • Cell biology

Background:

  • Phosphatidylserine (PS) and phosphatidylethanolamine (PE) are crucial signals for phagocytic clearance of apoptotic cells.
  • Liposomes are widely used drug delivery systems, and their biodistribution is key to efficacy.

Purpose of the Study:

  • To investigate and compare the in vivo biodistribution of liposomes containing different anionic phospholipids.
  • To understand how phospholipid composition influences the biodistribution of liposomes.

Main Methods:

  • Three types of phospholipid liposomes (DOPC/DOPS, DOPC/DOPE, DOPC/soybean PS) were prepared.
  • Liposomes were intravenously injected into subjects.
  • Biodistribution was analyzed by measuring radiant efficiency in various organs (lung, liver, kidney, heart).

Main Results:

  • DOPC/DOPS liposomes exhibited higher average radiant efficiency in the lung, liver, kidney, and heart compared to DOPC/DOPE liposomes.
  • DOPC/DOPS liposomes demonstrated significantly higher total and average radiant efficiency in the lung, liver, and kidney than DOPC/soybean PS liposomes.

Conclusions:

  • The biodistribution of anionic phospholipid liposomes is significantly influenced by their specific phospholipid composition.
  • These findings are critical for designing targeted liposomal drug delivery systems based on phospholipid characteristics.