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Updated: Jan 7, 2026

Preparation, Administration, and Assessment of In Vivo Tissue-Specific Cellular Uptake of Fluorescent Dye-Labeled Liposomes
Published on: July 30, 2020
Distinct Composition-dependent Biodis-tribution Patterns of Phospholipid Liposomes
Takahito Kawano1, Jeong-Hun Kang2, Masaharu Murata1,3
1Center for Advanced Medical Innovation, Kyushu University, 3-1-1 Maidashi, Higashi-ku, Fukuoka 812-8582, JAPAN.
Abstract:
Phosphatidylserine (PS) and phosphatidylethanolamine (PE) act as an "eat-me" signal for phagocytes to engulf apoptotic cells. The aim of our study was to investigate the biodistribution of PS- or PE-containing liposomes. Three phospholipid liposomes (DOPC/DOPS, DOPC/DOPE, and DOPC/soybean PS) were intravenously injected and analyzed. DOPC/DOPS showed higher average radiant efficiency (intensity/area) in the lung, liver, kidney, and heart than DOPC/DOPE. The total and average radiant efficiency of DOPC/DOPS was higher than that of DOPC/soybean PS in the lung, liver, and kidney. These results suggest that the biodistribution of anionic phospholipid liposomes depends on their phospholipid composition.
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