Related Experiment Video
Updated: Jan 7, 2026
12:24
A Three-Dimensional Spheroid Model to Investigate the Tumor-Stromal Interaction in Hepatocellular Carcinoma
Published on: September 30, 2021
5.9K
Survival Trends of Liver Cancer in 1975-2019 and Projection for 2020-2024: A 50-Year Analysis Using SEER Database
Yi-Xin Zou1,2,3, Zhuo-Jun Ye4, Zhuo-Ying Li2,3
1School of Public Health, Fudan University, Shanghai, China.
Journal of Digestive Diseases
|January 4, 2026
Summary
Primary liver cancer survival has improved over 45 years, but significant disparities persist based on age, sex, and race. Early detection and equitable care are crucial for improving outcomes in liver cancer patients.
Area of Science:
- Hepatology
- Oncology
- Epidemiology
Background:
- Primary liver cancer (PLC) is a major global cause of cancer mortality.
- Incidence and survival rates for PLC show concerning trends and disparities.
Purpose of the Study:
- To analyze long-term survival trends in primary liver cancer (PLC).
- To inform future prevention and treatment strategies for PLC.
Main Methods:
- Utilized the Surveillance, Epidemiology, and End Results (SEER) Program data (1975-2019).
- Employed model-based period analysis to assess survival rates stratified by age, sex, race, and tumor stage.
- Calculated observed survival rates (OSRs), relative survival rates (RSRs), conditional RSR (CRSR), and age-standardized RSR (ARSR).
Main Results:
- Female PLC patients exhibited higher 5-year age-standardized RSR (27.26%) than males (24.81%) from 2015-2019.
- Survival rates declined with age and advanced tumor stage, with distant cancer showing a 5.52% 5-year RSR in men.
- Black male patients had the lowest 5-year ARSR (19.61%), highlighting racial disparities. Projections indicate persistent survival gaps for older patients and black males.
Conclusions:
- Despite 45 years of improved PLC survival, significant disparities related to age, sex, race, and tumor stage persist.
- The findings emphasize the critical need for early detection and equitable healthcare access for PLC patients.
- Converging prognoses among long-term survivors underscore the importance of survivorship programs.
More Related Videos
07:13Comparison of Predictive Performance of Three Lymph Node Staging Systems in Colorectal Signet Ring Cell Carcinoma Based on Machine Learning Model
Published on: April 18, 2025
470
06:46Competing-Risk Nomogram for Predicting Cancer-Specific Survival in Multiple Primary Colorectal Cancer Patients after Surgery
Published on: September 27, 2024
619
Related Concept Videos
01:21Cancer Survival Analysis
626
Cancer survival analysis focuses on quantifying and interpreting the time from a key starting point, such as diagnosis or the initiation of treatment, to a specific endpoint, such as remission or death. This analysis provides critical insights into treatment effectiveness and factors that influence patient outcomes, helping to shape clinical decisions and guide prognostic evaluations. A cornerstone of oncology research, survival analysis tackles the challenges of skewed, non-normally...
626
02:57Targeted Cancer Therapies
8.6K
The targeted cancer therapies, also known as “molecular targeted therapies,” take advantage of the molecular and genetic differences between the cancer cells and the normal cells. It needs a thorough understanding of the cancer cells to develop drugs that can target specific molecular aspects that drive the growth, progression, and spread of cancer cells without affecting the growth and survival of other normal cells in the body.
There are several types of targeted therapies against...
There are several types of targeted therapies against...
8.6K
01:20Actuarial Approach
276
The actuarial approach, a statistical method originally developed for life insurance risk assessment, is widely used to calculate survival rates in clinical and population studies. This method accounts for participants lost to follow-up or those who die from causes unrelated to the study, ensuring a more accurate representation of survival probabilities.
Consider the example of a high-risk surgical procedure with significant early-stage mortality. A two-year clinical study is conducted,...
Consider the example of a high-risk surgical procedure with significant early-stage mortality. A two-year clinical study is conducted,...
276
01:26Diseases of the Liver and Gallbladder
1.8K
Liver and gallbladder diseases are a significant health concern, with prominent conditions including cirrhosis, hepatitis, non-alcoholic fatty liver disease (NAFLD), and gallstones. Jaundice is a common manifestation of liver and biliary disease.
Cirrhosis is characterized by the scarring of hepatic lobules in the liver, which are replaced by fibrous tissue, affecting the liver's normal functioning. NAFLD, on the other hand, is caused by an excessive build-up of fat in the liver, not...
Cirrhosis is characterized by the scarring of hepatic lobules in the liver, which are replaced by fibrous tissue, affecting the liver's normal functioning. NAFLD, on the other hand, is caused by an excessive build-up of fat in the liver, not...
1.8K
01:22Life Tables
472
A life table is a statistical tool that summarizes the mortality and survival patterns of a population, providing detailed insights into the likelihood of survival or death across different age intervals within a cohort. By organizing data on survival probabilities and mortality rates, life tables offer a clear snapshot of population dynamics over time. They are extensively used in demography, public health, actuarial science, and ecology to analyze life expectancy, design health interventions,...
472
01:22Applications of Life Tables
309
Life tables are versatile across various fields, providing a quantitative basis for analyzing mortality and survival rates. Whether used by demographers, actuaries, epidemiologists, or sociologists, life tables offer valuable insights into the dynamics of life and death, facilitating informed decisions in public health, insurance, conservation, and beyond. Their broad applicability highlights the interconnectedness of demographic data with practical outcomes in everyday life and strategic...
309