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Updated: Jan 7, 2026
09:58
Lipidomics and Transcriptomics in Neurological Diseases
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Pro-resolving lipid mediators in diseases: exploring the molecular basis and clinical implication
Chaofu Li1, Zimu Wang2, Yukun Yang3
1Department of Cardiology, Chongqing University Central Hospital (Chongqing Emergency Medical Center), College of Bioengineering, Chongqing University, Chongqing, 400014, China.
Molecular Biomedicine
|January 4, 2026
Summary
Inflammation resolution is an active process. Specialized pro-resolving lipid mediators (PRLMs) restore immune balance, offering new therapeutic strategies beyond conventional anti-inflammatory drugs.
Area of Science:
- Immunology
- Molecular Biology
- Pharmacology
Background:
- Inflammation resolution is an active biological process, not passive.
- Failure to resolve inflammation leads to chronic diseases like cardiovascular disorders and neurodegeneration.
- Conventional anti-inflammatory drugs suppress inflammation but do not promote resolution or immune balance.
Purpose of the Study:
- To review advances in pro-resolving lipid mediators (PRLMs).
- To discuss PRLM biosynthesis, signaling, and functions in disease.
- To explore therapeutic strategies and challenges for clinical translation.
Main Methods:
- Literature review of recent studies on PRLMs.
- Analysis of PRLM roles in efferocytosis, cytokine networks, and leukocyte trafficking.
- Examination of receptor-dependent signaling pathways.
Main Results:
- PRLMs actively promote inflammation resolution and tissue regeneration.
- PRLMs restore immune homeostasis, unlike conventional anti-inflammatories.
- Challenges include rapid inactivation and delivery strategies for PRLMs.
Conclusions:
- PRLMs represent a paradigm shift from inhibiting inflammation to restoring immune balance.
- PRLM research offers a promising framework for novel therapeutic interventions.
- Further research is needed to overcome clinical translation challenges.
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