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Update on an Expanded Targeted Early Cytomegalovirus Testing Program From a Large Health Care System

Peter Kfoury1, Megna D Reddy1, Albert H Park1,2

  • 1Department of Otolaryngology - Head and Neck Surgery, University of Utah School of Medicine, Salt Lake City, UT.

Otology & Neurotology : Official Publication of the American Otological Society, American Neurotology Society [And] European Academy of Otology and Neurotology
|January 5, 2026
PubMed

Insights

An expanded screening program effectively detected congenital cytomegalovirus (cCMV) in Utah newborns. Early detection enabled timely interventions for affected infants, improving outcomes.

Area of Science:

  • Neonatal screening
  • Public health
  • Infectious disease surveillance

Background:

  • Congenital cytomegalovirus (cCMV) is a leading infectious cause of non-genetic hearing loss in newborns.
  • Early detection and intervention are crucial for mitigating long-term neurodevelopmental consequences.

Purpose of the Study:

  • To evaluate the effectiveness of an expanded targeted screening program for cCMV detection in a large healthcare system.
  • To determine the prevalence of cCMV and associated clinical characteristics in the screened population.

Main Methods:

  • Retrospective cohort study analyzing data from Intermountain Healthcare (IHC) in Utah.
  • Infants born between March 1, 2021, and August 31, 2024, were screened for cCMV within six months of birth.
  • Data collected included screening test orders, live births, confirmed cCMV cases, and audiological outcomes.

Main Results:

  • Over 3.5 years, 8598 cCMV screening tests were performed among 93,529 live births.
  • The program identified 32 confirmed cCMV cases, resulting in an estimated prevalence of 34 cases per 100,000 live births.
  • Hearing loss was diagnosed in 28% (9/32) of cCMV-positive infants, with 8 children receiving hearing aids or cochlear implants.

Conclusions:

  • The expanded targeted cCMV testing program is effective in identifying newborns with cCMV.
  • Early detection facilitates timely intervention, highlighting the program's feasibility and potential for improved infant outcomes.
  • This approach offers opportunities for enhanced early intervention and treatment strategies for cCMV.
Abstract

Keywords:
CMVCongenitalCytomegalovirusHearing lossInfectionNewbornScreeningSensorineuralTORCH infection

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