High rate of functional cure in infants with chronic hepatitis B following a definite duration of antiviral treatment
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View abstract on PubMed
Summary
This summary is machine-generated.Antiviral treatment with Lamivudine and Interferon-alfa can lead to a functional cure in infants with chronic hepatitis B. This study shows high success rates for achieving undetectable HBV DNA and HBeAg seroconversion.
Area Of Science
- Pediatrics
- Hepatology
- Virology
Background
- Limited data exists on antiviral therapies for infants diagnosed with chronic hepatitis B (CHB).
- Investigating the efficacy of antiviral treatment for achieving a functional cure in infants with CHB is crucial.
Purpose Of The Study
- To assess the effectiveness of antiviral treatment in achieving a functional cure for CHB in infants.
- To evaluate the virological response and safety of Lamivudine plus Interferon-alfa therapy in this population.
Main Methods
- A real-world study involving 21 infants (median age 9 months) with HBeAg-positive CHB.
- Treatment involved initial Lamivudine monotherapy, with Interferon-alfa added after 12 months of age.
- Analysis of virological responses, functional cure rates, and safety over 36 months.
Main Results
- All infants achieved viral suppression, with undetectable HBV DNA in a median of 6 months.
- HBeAg seroconversion occurred in 20 out of 21 infants within a median of 7 months.
- 19 out of 21 infants achieved a functional cure within a median of 9 months; no serious adverse events were reported.
Conclusions
- Infants under one year with CHB can achieve a high probability of functional cure with Lamivudine add-on Interferon-alfa therapy.
- A defined duration of antiviral treatment is effective for achieving sustained virological response and functional cure.
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