Related Experiment Video
Updated: Jan 7, 2026
The Establishment and Utilization of Patient Derived Xenograft Models of Central Nervous System Metastasis
Published on: May 7, 2021
Establishment of a Patient-Derived Xenograft Model of a Testicular Yolk Sac Tumor
Nobuhiko Shimizu1, Taku Naiki1,2, Aya Naiki-Ito3
1Department of Nephro-urology, Nagoya City University, Graduate School of Medical Sciences, Nagoya, Japan.
Abstract:
We have established a highly stable and reproducible patient derived xenograft model that exclusively and robustly retains the morphological, functional, and proliferative characteristics of human yolk sac tumor of the testis. This model might provide an invaluable in vivo platform for accelerating the discovery and validation of novel therapeutic strategies for this aggressive malignancy, with the ultimate aim of improving the prognosis for affected patients.
