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Related Experiment Video

Updated: Jan 7, 2026

Evaluation of the Feasibility, Safety, and Accuracy of an Intraoperative High-intensity Focused Ultrasound Device for Treating Liver Metastases
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RADIOFREQUENCY ABLATION AS PART OF INTRAHEPATIC TREATMENT STRATEGIES.

K Valikhnovska1, A Lukashenko1

  • 1State Non-commercial Enterprise "National Cancer Institute", Kyiv, Ukraine.

Experimental Oncology
|January 5, 2026
PubMed
Summary
This summary is machine-generated.

Radiofrequency ablation (RFA) offers a safe alternative for treating colorectal liver metastases when resection is not feasible. Survival outcomes are significantly influenced by the timing and presence of metastases.

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Area of Science:

  • Oncology
  • Hepatobiliary Surgery
  • Minimally Invasive Procedures

Background:

  • Liver resection is the standard for colorectal liver metastases.
  • Radiofrequency ablation (RFA) is an alternative for unresectable or parenchyma-sparing treatments.
  • RFA's efficacy in intraparenchymal colorectal liver metastases requires analysis.

Purpose of the Study:

  • To analyze treatment outcomes and survival after RFA for colorectal liver metastases.
  • To identify prognostic factors influencing survival post-RFA.
  • To evaluate RFA as an alternative to resection.

Main Methods:

  • Retrospective analysis of 33 patients undergoing RFA (2013-2023).
  • Used Cool-tip RF Ablation System with cooled monopolar needles (3cm tip).
  • Intraoperative ultrasound guidance was employed.

Main Results:

  • Survival significantly impacted by synchronous (p<0.001) and metachronous (p<0.001) metastases.
  • Median time to progression differed significantly between survival groups (p=0.0004).
  • No significant impact from sex, age, tumor characteristics, chemotherapy, or comorbidities.

Conclusions:

  • RFA is a safe alternative for unresectable colorectal liver metastases or in parenchyma-sparing strategies.
  • Liver resection remains the priority when feasible; combining RFA and resection expands eligibility.
  • Further randomized studies are needed to confirm RFA efficacy and identify optimal patient candidates.