EFFECT OF HYPOXIA ON MICROENVIRONMENT FACTORS OF GASTRIC CANCER AND RELATIONSHIP WITH CLINICAL OUTCOME

The tumor microenvironment (TME) plays a critical role in tumor survival, progression, and metastasis. Нypoxia level, as an integral parameter of TME, occupies a central place in the regulation and control of all events occurring in TME. The review focuses on the findings obtained by the authors during the study of the hypoxia impact on the processes related to some microenvironmental factors in order to identify its prognostic significance regarding the course of the disease. It was shown that most microenvironmental factors are largely associated with hypoxia and involved in the processes of the tumor response to therapy. Their significance in the development of minimal residual disease and in the processes that can be affected by adipose tissue is also discussed. Therapeutic strategies based on the tumor's distinctive properties should be more highly selective in relation to the tumor, allowing the highest possible therapeutic gain for a more favorable prognosis of the disease outcome and overall survival of patients with gastric cancer. The literature data on the subject are also discussed.